Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats
Background & Aim: Considering the evidence which show the effect of herbal medicine on renal stone treatment, the aim of this study was to evaluate the efficacy of Allium Jesdianum on prevention and treatment of calcium oxalate stone in rats. Methods: In the present experimental study, forty...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2012-02-01
|
| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-166&slc_lang=en&sid=1 |
| _version_ | 1818018680100880384 |
|---|---|
| author | R Vahdani S Mehrabi J Malekzadeh R Jannesar H Sadeghi A Shafaeifar |
| author_facet | R Vahdani S Mehrabi J Malekzadeh R Jannesar H Sadeghi A Shafaeifar |
| author_sort | R Vahdani |
| collection | DOAJ |
| description | Background & Aim: Considering the evidence which show the effect of herbal medicine on renal stone treatment, the aim of this study was to evaluate the efficacy of Allium Jesdianum on prevention and treatment of calcium oxalate stone in rats.
Methods: In the present experimental study, forty-four male Wistar rats were randomly divided into four groups (each group 11 rats) and then studied for 30 days. The Healthy control group only received normal water and a regular diet. The negative control group received 1% ethylene glycol in water during the study. The low dose and high dose preventive groups received 750 mg/kg and 1500 mg/kg of Allium Jesdianum with 1% ethylene glycol every day. The 24-hour urine samples of rats were collected on days 1, 15 and 30 of the study. Then, under anesthesia, blood samples were taken directly from the heart. All rats were then killed and pathology of kidneys was checked for crystals of calcium oxalates in renal tubules. Data analysis was done by the SPSS software using One-way ANOVA.
Results: The number of calcium oxalate crystals in the negative control group (18.7 ±26.1), the low dose preventive group (5.3±8.2) and high dose preventive group (80.6±82.8) in comparison to the healthy control group were increased and this difference in the high dose preventive group and healthy control group was significant (p <0.05) . Urinary oxalate in the 30th day was more in both preventive groups and negative control group in comparison to healthy control group and this diference was statistically significant (p <0.05).
Conclusion: This study showed that Allium Jesdianum doesn't have a preventive effect on the formation of renal stones, and it also increases calcium oxalate crystals in kidney of male wistar rats that need more studies. |
| first_indexed | 2024-04-14T07:43:11Z |
| format | Article |
| id | doaj.art-4abd2bc9a2d84594ad4dda820ec088da |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-14T07:43:11Z |
| publishDate | 2012-02-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-4abd2bc9a2d84594ad4dda820ec088da2022-12-22T02:05:26ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142012-02-01166566577Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar RatsR Vahdani0S Mehrabi1J Malekzadeh2R Jannesar3H Sadeghi4A Shafaeifar5 Background & Aim: Considering the evidence which show the effect of herbal medicine on renal stone treatment, the aim of this study was to evaluate the efficacy of Allium Jesdianum on prevention and treatment of calcium oxalate stone in rats. Methods: In the present experimental study, forty-four male Wistar rats were randomly divided into four groups (each group 11 rats) and then studied for 30 days. The Healthy control group only received normal water and a regular diet. The negative control group received 1% ethylene glycol in water during the study. The low dose and high dose preventive groups received 750 mg/kg and 1500 mg/kg of Allium Jesdianum with 1% ethylene glycol every day. The 24-hour urine samples of rats were collected on days 1, 15 and 30 of the study. Then, under anesthesia, blood samples were taken directly from the heart. All rats were then killed and pathology of kidneys was checked for crystals of calcium oxalates in renal tubules. Data analysis was done by the SPSS software using One-way ANOVA. Results: The number of calcium oxalate crystals in the negative control group (18.7 ±26.1), the low dose preventive group (5.3±8.2) and high dose preventive group (80.6±82.8) in comparison to the healthy control group were increased and this difference in the high dose preventive group and healthy control group was significant (p <0.05) . Urinary oxalate in the 30th day was more in both preventive groups and negative control group in comparison to healthy control group and this diference was statistically significant (p <0.05). Conclusion: This study showed that Allium Jesdianum doesn't have a preventive effect on the formation of renal stones, and it also increases calcium oxalate crystals in kidney of male wistar rats that need more studies.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-166&slc_lang=en&sid=1Allium Jesdianum Nephrolithiasis ethylene glycol calcium oxalate |
| spellingShingle | R Vahdani S Mehrabi J Malekzadeh R Jannesar H Sadeghi A Shafaeifar Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats Armaghane Danesh Bimonthly Journal Allium Jesdianum Nephrolithiasis ethylene glycol calcium oxalate |
| title | Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats |
| title_full | Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats |
| title_fullStr | Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats |
| title_full_unstemmed | Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats |
| title_short | Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats |
| title_sort | effect of hydrophilic extract of allium jesdianum on ethylene glycol induced renal stone in male wistar rats |
| topic | Allium Jesdianum Nephrolithiasis ethylene glycol calcium oxalate |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-166&slc_lang=en&sid=1 |
| work_keys_str_mv | AT rvahdani effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats AT smehrabi effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats AT jmalekzadeh effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats AT rjannesar effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats AT hsadeghi effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats AT ashafaeifar effectofhydrophilicextractofalliumjesdianumonethyleneglycolinducedrenalstoneinmalewistarrats |