Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study
Introduction : In addition to changes in seizure frequency, pregnant women with epilepsy (WWE) are at increased risk of complications during pregnancy or delivery. In the absence of a nationwide WWE registry, hospital-based studies may provide important information regarding current management and o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=534;epage=537;aulast=Othman |
| _version_ | 1818547259193688064 |
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| author | Noor Haslina Othman Ab Fatah Ab Rahman |
| author_facet | Noor Haslina Othman Ab Fatah Ab Rahman |
| author_sort | Noor Haslina Othman |
| collection | DOAJ |
| description | Introduction : In addition to changes in seizure frequency, pregnant women with epilepsy (WWE) are at increased risk of complications during pregnancy or delivery. In the absence of a nationwide WWE registry, hospital-based studies may provide important information regarding current management and outcomes in these patients. Objectives: The aims of this study were to determine changes in seizure frequency, and pregnancy and birth outcomes among pregnant WWE. Materials and Methods: We conducted a retrospective review of medical records of pregnant patients with epilepsy, who obtained medical care (from 2006 to 2011) at one of the general hospitals in the North-Eastern State of Malaysia. Data were collected for seizure frequency before and during the pregnancy, concurrent medications, pregnancy complications, and neonatal outcomes. Results: We reviewed records of 25 patients with a total of 33 different pregnancies. All patients were treated with antiepileptic medications during their pregnancies, with 42% monotherapy and 58% polytherapy. Seizure frequency decreased in 5 (15.2%), increased in 18 (54.5%) and unchanged in 10 (30.3%) cases of pregnancies. Pregnancy complications were anemia, gestational diabetes mellitus, gestational hypertension, intrauterine growth retardation, premature rupture of membrane, and vaginal bleeding. Preterm deliveries were recorded in 11 (33.3%) infants. Conclusion: In our setting, many patients were being on polytherapy during their pregnancies. This underscores the need for planned pregnancies so that antiepileptic medications can be optimized prior to pregnancy. |
| first_indexed | 2024-12-12T08:04:22Z |
| format | Article |
| id | doaj.art-4abe3a10b05b4044a9c3ed4917e4a47c |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-12T08:04:22Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-4abe3a10b05b4044a9c3ed4917e4a47c2022-12-22T00:32:00ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492013-01-0116453453710.4103/0972-2327.120458Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based studyNoor Haslina OthmanAb Fatah Ab RahmanIntroduction : In addition to changes in seizure frequency, pregnant women with epilepsy (WWE) are at increased risk of complications during pregnancy or delivery. In the absence of a nationwide WWE registry, hospital-based studies may provide important information regarding current management and outcomes in these patients. Objectives: The aims of this study were to determine changes in seizure frequency, and pregnancy and birth outcomes among pregnant WWE. Materials and Methods: We conducted a retrospective review of medical records of pregnant patients with epilepsy, who obtained medical care (from 2006 to 2011) at one of the general hospitals in the North-Eastern State of Malaysia. Data were collected for seizure frequency before and during the pregnancy, concurrent medications, pregnancy complications, and neonatal outcomes. Results: We reviewed records of 25 patients with a total of 33 different pregnancies. All patients were treated with antiepileptic medications during their pregnancies, with 42% monotherapy and 58% polytherapy. Seizure frequency decreased in 5 (15.2%), increased in 18 (54.5%) and unchanged in 10 (30.3%) cases of pregnancies. Pregnancy complications were anemia, gestational diabetes mellitus, gestational hypertension, intrauterine growth retardation, premature rupture of membrane, and vaginal bleeding. Preterm deliveries were recorded in 11 (33.3%) infants. Conclusion: In our setting, many patients were being on polytherapy during their pregnancies. This underscores the need for planned pregnancies so that antiepileptic medications can be optimized prior to pregnancy.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=534;epage=537;aulast=OthmanEpilepsyoutcomespregnancywomen |
| spellingShingle | Noor Haslina Othman Ab Fatah Ab Rahman Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study Annals of Indian Academy of Neurology Epilepsy outcomes pregnancy women |
| title | Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study |
| title_full | Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study |
| title_fullStr | Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study |
| title_full_unstemmed | Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study |
| title_short | Obstetric and birth outcomes in pregnant women with epilepsy: A hospital-based study |
| title_sort | obstetric and birth outcomes in pregnant women with epilepsy a hospital based study |
| topic | Epilepsy outcomes pregnancy women |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=534;epage=537;aulast=Othman |
| work_keys_str_mv | AT noorhaslinaothman obstetricandbirthoutcomesinpregnantwomenwithepilepsyahospitalbasedstudy AT abfatahabrahman obstetricandbirthoutcomesinpregnantwomenwithepilepsyahospitalbasedstudy |