Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases
Abstract Liver damage caused by toxicity can lead to various severe conditions, such as acute liver failure (ALF), fibrogenesis, and cirrhosis. Among these, liver cirrhosis (LC) is recognized as the leading cause of liver-related deaths globally. Unfortunately, patients with progressive cirrhosis ar...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03364-x |
| _version_ | 1827940036392255488 |
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| author | Farnaz Sani Mahsa Sani Zahra Moayedfard Maryam Darayee Lobat Tayebi Negar Azarpira |
| author_facet | Farnaz Sani Mahsa Sani Zahra Moayedfard Maryam Darayee Lobat Tayebi Negar Azarpira |
| author_sort | Farnaz Sani |
| collection | DOAJ |
| description | Abstract Liver damage caused by toxicity can lead to various severe conditions, such as acute liver failure (ALF), fibrogenesis, and cirrhosis. Among these, liver cirrhosis (LC) is recognized as the leading cause of liver-related deaths globally. Unfortunately, patients with progressive cirrhosis are often on a waiting list, with limited donor organs, postoperative complications, immune system side effects, and high financial costs being some of the factors restricting transplantation. Although the liver has some capacity for self-renewal due to the presence of stem cells, it is usually insufficient to prevent the progression of LC and ALF. One potential therapeutic approach to improving liver function is the transplantation of gene-engineered stem cells. Several types of mesenchymal stem cells from various sources have been suggested for stem cell therapy for liver disease. Genetic engineering is an effective strategy that enhances the regenerative potential of stem cells by releasing growth factors and cytokines. In this review, we primarily focus on the genetic engineering of stem cells to improve their ability to treat damaged liver function. We also recommend further research into accurate treatment methods that involve safe gene modification and long-term follow-up of patients to increase the effectiveness and reliability of these therapeutic strategies. |
| first_indexed | 2024-03-13T09:03:31Z |
| format | Article |
| id | doaj.art-4abe57a1bd1842de9492d9630c5fc6a4 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-13T09:03:31Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-4abe57a1bd1842de9492d9630c5fc6a42023-05-28T11:09:59ZengBMCStem Cell Research & Therapy1757-65122023-05-0114111110.1186/s13287-023-03364-xPotential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseasesFarnaz Sani0Mahsa Sani1Zahra Moayedfard2Maryam Darayee3Lobat Tayebi4Negar Azarpira5Hematology and Cell Therapy Department, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical SciencesDepartment of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical SciencesDepartment of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical SciencesMarquette University School of DentistryTransplant Research Center, Shiraz University of Medical SciencesAbstract Liver damage caused by toxicity can lead to various severe conditions, such as acute liver failure (ALF), fibrogenesis, and cirrhosis. Among these, liver cirrhosis (LC) is recognized as the leading cause of liver-related deaths globally. Unfortunately, patients with progressive cirrhosis are often on a waiting list, with limited donor organs, postoperative complications, immune system side effects, and high financial costs being some of the factors restricting transplantation. Although the liver has some capacity for self-renewal due to the presence of stem cells, it is usually insufficient to prevent the progression of LC and ALF. One potential therapeutic approach to improving liver function is the transplantation of gene-engineered stem cells. Several types of mesenchymal stem cells from various sources have been suggested for stem cell therapy for liver disease. Genetic engineering is an effective strategy that enhances the regenerative potential of stem cells by releasing growth factors and cytokines. In this review, we primarily focus on the genetic engineering of stem cells to improve their ability to treat damaged liver function. We also recommend further research into accurate treatment methods that involve safe gene modification and long-term follow-up of patients to increase the effectiveness and reliability of these therapeutic strategies.https://doi.org/10.1186/s13287-023-03364-xGenetic engineeringStem cellsCell therapyCirrhosisLiver disease |
| spellingShingle | Farnaz Sani Mahsa Sani Zahra Moayedfard Maryam Darayee Lobat Tayebi Negar Azarpira Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases Stem Cell Research & Therapy Genetic engineering Stem cells Cell therapy Cirrhosis Liver disease |
| title | Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| title_full | Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| title_fullStr | Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| title_full_unstemmed | Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| title_short | Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| title_sort | potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases |
| topic | Genetic engineering Stem cells Cell therapy Cirrhosis Liver disease |
| url | https://doi.org/10.1186/s13287-023-03364-x |
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