Four Novel <i>PAX9</i> Variants and the <i>PAX9</i>-Related Non-Syndromic Tooth Agenesis Patterns

Four Novel <i>PAX9</i> Variants and the <i>PAX9</i>-Related Non-Syndromic Tooth Agenesis Patterns

The purpose of this research was to investigate and identify <i>PAX9</i> gene variants in four Chinese families with non-syndromic tooth agenesis. We identified pathogenic gene variants by whole-exome sequencing (WES) and Sanger sequencing and then studied the effects of these variants o...

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Bibliographic Details
Main Authors: Haochen Liu, Hangbo Liu, Lanxin Su, Jinglei Zheng, Hailan Feng, Yang Liu, Miao Yu, Dong Han
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
tooth agenesis
<i>PAX9</i> variants
functional studies
phenotypic analysis
Online Access:https://www.mdpi.com/1422-0067/23/15/8142

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