Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units
<b>Background</b>: Aminoglycosides are the most prescribed antibiotics in neonatal intensive care units (NICU). Reducing exposure to antibiotics in the NICU is highly desirable, particularly through benchmarking methods. <b>Methods:</b> Description of aminoglycosides prescrip...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
MDPI AG
2021-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Acceso en liña: | https://www.mdpi.com/2079-6382/10/11/1422 |
| _version_ | 1827677512740634624 |
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| author | Séverine Martin-Mons Béatrice Gouyon Séverine Lorrain Soumeth Abasse Cénéric Alexandre Guillaume Binson Roselyne Brat Laurence Caeymaex Yvan Couringa Cécile Desbruyeres Marine Dorsi-Di Meglio Guillaume Escourrou Florence Flamein Olivier Flechelles Olivier Girard Elsa Kermorvant-Duchemin Alexandre Lapillonne Catherine Lafon Massimo Di Maio Gaël Mazeiras Julien Mourdie Amélie Moussy-Durandy Anne-Sophie Pages Duksha Ramful Hasinirina Razafimahefa Jean-Marc Rosenthal Silvia Iacobelli Jean-Bernard Gouyon |
| author_facet | Séverine Martin-Mons Béatrice Gouyon Séverine Lorrain Soumeth Abasse Cénéric Alexandre Guillaume Binson Roselyne Brat Laurence Caeymaex Yvan Couringa Cécile Desbruyeres Marine Dorsi-Di Meglio Guillaume Escourrou Florence Flamein Olivier Flechelles Olivier Girard Elsa Kermorvant-Duchemin Alexandre Lapillonne Catherine Lafon Massimo Di Maio Gaël Mazeiras Julien Mourdie Amélie Moussy-Durandy Anne-Sophie Pages Duksha Ramful Hasinirina Razafimahefa Jean-Marc Rosenthal Silvia Iacobelli Jean-Bernard Gouyon |
| author_sort | Séverine Martin-Mons |
| collection | DOAJ |
| description | <b>Background</b>: Aminoglycosides are the most prescribed antibiotics in neonatal intensive care units (NICU). Reducing exposure to antibiotics in the NICU is highly desirable, particularly through benchmarking methods. <b>Methods:</b> Description of aminoglycosides prescriptions in 23 French NICU using the same computerized system over a 4-year period (2017–2020). A benchmarking program of antibiotics prescription was associated. <b>Results:</b> The population included 53,818 patients. Exposition rates to gentamicin and amikacin were 31.7% (<i>n</i> = 17,049) and 9.1% (<i>n</i> = 4894), respectively. Among neonates exposed to gentamicin, 90.4% of gentamicin and 77.6% of amikacin treatments were started within the 1st week of life. Among neonates exposed to amikacin, 77.6% started amikacin within the 1st week. The average daily dose of gentamicin at first prescription increased over the study period from 3.9 in 2017 to 4.4 mg/kg/d in 2020 (<i>p</i> < 0.0001). Conversely, the corresponding amikacin daily doses decreased from 13.0 in 2017 to 12.3 mg/kg/d in 2020 (<i>p</i> = 0.001). The time interval between the first 2 doses of gentamicin was mainly distributed in 3 values during the first week of life: 49.4% at 24 h, 26.4% at 36 h, and 22.9% at 48 h. At first amikacin prescription, the time interval was distributed in 4 categories: 48% at 24 h, 4.1% at 30 h, 8.5% at 36 h, and 37.1% at 48 h. As compared to literature guidelines, the rates of overdose and underdose in gentamicin (1.5% and 2.7%) and amikacin (0.3% and 1.0%). They significantly decreased for gentamicin over the study period. In multivariate analysis, the factors significantly associated with GENT overdose were the year of admission, prematurity, length of stay, and duration of the treatment. <b>Conclusion:</b> This prescription strategy ensured a low rate of overdose and underdose, and some benefits of the benchmarking program is suggested. |
| first_indexed | 2024-03-10T05:45:03Z |
| format | Article |
| id | doaj.art-4ac2fb44f8b548ebbdc3e9c73b5c20e2 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T05:45:03Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-4ac2fb44f8b548ebbdc3e9c73b5c20e22023-11-22T22:11:26ZengMDPI AGAntibiotics2079-63822021-11-011011142210.3390/antibiotics10111422Prescription of Aminoglycosides in 23 French Neonatal Intensive Care UnitsSéverine Martin-Mons0Béatrice Gouyon1Séverine Lorrain2Soumeth Abasse3Cénéric Alexandre4Guillaume Binson5Roselyne Brat6Laurence Caeymaex7Yvan Couringa8Cécile Desbruyeres9Marine Dorsi-Di Meglio10Guillaume Escourrou11Florence Flamein12Olivier Flechelles13Olivier Girard14Elsa Kermorvant-Duchemin15Alexandre Lapillonne16Catherine Lafon17Massimo Di Maio18Gaël Mazeiras19Julien Mourdie20Amélie Moussy-Durandy21Anne-Sophie Pages22Duksha Ramful23Hasinirina Razafimahefa24Jean-Marc Rosenthal25Silvia Iacobelli26Jean-Bernard Gouyon27Centre D’Etudes Périnatales de L’Océan Indien (UR 7388), Université de La Réunion, 97410 Saint-Pierre, FranceSociété LogipremF, 97410 Saint-Pierre, FranceCentre D’Etudes Périnatales de L’Océan Indien (UR 7388), Université de La Réunion, 97410 Saint-Pierre, FranceCentre Hospitalier de Mayotte, 97600 Mayotte, FranceCentre Hospitalier Universitaire de Caen, 14000 Caen, FranceCentre Hospitalier Universitaire de Poitiers, 86000 Poitiers, FranceCentre Hospitalier Régional d’Orléans, 45100 Orléans, FranceCentre Hospitalier Intercommunal de Créteil, 94000 Créteil, FranceCentre Hospitalier Andrée-Rosemont, 97300 Guyane, FranceCentre Hospitalier Métropole Savoie, 73000 Chambéry, FranceCentre Hospitalier Territorial Gaston-Bourret, 98800 Nouméa, FranceCentre Hospitalier Intercommunal André Grégoire, 93100 Montreuil, FranceCentre Hospitalier Universitaire de Lille, 59000 Lille, FranceCentre Hospitalier Universitaire de Fort-de-France, 97200 Martinique, FranceCentre Hospitalier de Saint-Denis, 93200 Saint-Denis, FranceFrench Society of Neonatology, 93200 Ecouen, FranceAPHP Hôpital Necker-Enfants Malades, 75015 Paris, FranceCentre Hospitalier d’Arras, 62000 Arras, FranceCentre Hospitalier Universitaire de Nîmes, 30900 Nîmes, FranceCentre Hospitalier de la Côte Basque, 64100 Bayonne, FranceHôpital Jacques Monod, Groupe Hospitalier du Havre, 76290 Montvilliers, FranceCentre Hospitalier Intercommunal Poissy, 78300 Poissy, FranceCentre Hospitalier Public du Cotentin, 50100 Cherbourg-en-Cotentin, FranceCentre Hospitalier Universitaire-Site Nord, Saint-Denis, 97400 Réunion, FranceCentre Hospitalier Sud Francilien, 91100 Corbeil-Essonnes, FranceCentre Hospitalier Universitaire de Pointe-à-Pitre, 97110 Guadeloupe, FranceCentre D’Etudes Périnatales de L’Océan Indien (UR 7388), Université de La Réunion, 97410 Saint-Pierre, FranceCentre D’Etudes Périnatales de L’Océan Indien (UR 7388), Université de La Réunion, 97410 Saint-Pierre, France<b>Background</b>: Aminoglycosides are the most prescribed antibiotics in neonatal intensive care units (NICU). Reducing exposure to antibiotics in the NICU is highly desirable, particularly through benchmarking methods. <b>Methods:</b> Description of aminoglycosides prescriptions in 23 French NICU using the same computerized system over a 4-year period (2017–2020). A benchmarking program of antibiotics prescription was associated. <b>Results:</b> The population included 53,818 patients. Exposition rates to gentamicin and amikacin were 31.7% (<i>n</i> = 17,049) and 9.1% (<i>n</i> = 4894), respectively. Among neonates exposed to gentamicin, 90.4% of gentamicin and 77.6% of amikacin treatments were started within the 1st week of life. Among neonates exposed to amikacin, 77.6% started amikacin within the 1st week. The average daily dose of gentamicin at first prescription increased over the study period from 3.9 in 2017 to 4.4 mg/kg/d in 2020 (<i>p</i> < 0.0001). Conversely, the corresponding amikacin daily doses decreased from 13.0 in 2017 to 12.3 mg/kg/d in 2020 (<i>p</i> = 0.001). The time interval between the first 2 doses of gentamicin was mainly distributed in 3 values during the first week of life: 49.4% at 24 h, 26.4% at 36 h, and 22.9% at 48 h. At first amikacin prescription, the time interval was distributed in 4 categories: 48% at 24 h, 4.1% at 30 h, 8.5% at 36 h, and 37.1% at 48 h. As compared to literature guidelines, the rates of overdose and underdose in gentamicin (1.5% and 2.7%) and amikacin (0.3% and 1.0%). They significantly decreased for gentamicin over the study period. In multivariate analysis, the factors significantly associated with GENT overdose were the year of admission, prematurity, length of stay, and duration of the treatment. <b>Conclusion:</b> This prescription strategy ensured a low rate of overdose and underdose, and some benefits of the benchmarking program is suggested.https://www.mdpi.com/2079-6382/10/11/1422n/a |
| spellingShingle | Séverine Martin-Mons Béatrice Gouyon Séverine Lorrain Soumeth Abasse Cénéric Alexandre Guillaume Binson Roselyne Brat Laurence Caeymaex Yvan Couringa Cécile Desbruyeres Marine Dorsi-Di Meglio Guillaume Escourrou Florence Flamein Olivier Flechelles Olivier Girard Elsa Kermorvant-Duchemin Alexandre Lapillonne Catherine Lafon Massimo Di Maio Gaël Mazeiras Julien Mourdie Amélie Moussy-Durandy Anne-Sophie Pages Duksha Ramful Hasinirina Razafimahefa Jean-Marc Rosenthal Silvia Iacobelli Jean-Bernard Gouyon Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units Antibiotics n/a |
| title | Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units |
| title_full | Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units |
| title_fullStr | Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units |
| title_full_unstemmed | Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units |
| title_short | Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units |
| title_sort | prescription of aminoglycosides in 23 french neonatal intensive care units |
| topic | n/a |
| url | https://www.mdpi.com/2079-6382/10/11/1422 |
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