Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective
Ulcer is one of the most common diseases affecting throughout the world population. The allopathic treatment of ulcer adversely affects the health by causing harmful side effects. Currently, many herbal plants and secondary metabolites have been used for the ulcer treatment. In the present review, m...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X17303430 |
| _version_ | 1828491019666063360 |
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| author | Amit Kishore Singh Sandeep Kumar Singh Prem Pratap Singh Akhileshwar Kumar Srivastava Kapil D. Pandey Ajay Kumar Himanshu Yadav |
| author_facet | Amit Kishore Singh Sandeep Kumar Singh Prem Pratap Singh Akhileshwar Kumar Srivastava Kapil D. Pandey Ajay Kumar Himanshu Yadav |
| author_sort | Amit Kishore Singh |
| collection | DOAJ |
| description | Ulcer is one of the most common diseases affecting throughout the world population. The allopathic treatment of ulcer adversely affects the health by causing harmful side effects. Currently, many herbal plants and secondary metabolites have been used for the ulcer treatment. In the present review, many herbal plants and their parts (root, rhizome, bark, leaves and fruits) have been listed in the table are currently being used for ulcer treatment. These metabolites are responsible for ulcer-neutralization or anti-inflammatory properties. In silico study, plant metabolites showed interaction between protodioscin (secondary metabolites of Asparagus racemosus) and interferon-γ (virulent factor of gastric ulcer) during molecular docking. All the residues of interferon-γ exhibited hydrophobic interactions with plant metabolites. These interactions helps in understanding the plant secondary metabolites vis a vis will open a new door in the research field of new drug discovery and designing for the ulcer treatment. |
| first_indexed | 2024-12-11T10:54:52Z |
| format | Article |
| id | doaj.art-4ac3836160a94ea4bc7a2a73d1292157 |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-12-11T10:54:52Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-4ac3836160a94ea4bc7a2a73d12921572022-12-22T01:10:08ZengElsevierBiotechnology Reports2215-017X2018-06-0118C10.1016/j.btre.2018.e00256Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospectiveAmit Kishore Singh0Sandeep Kumar Singh1Prem Pratap Singh2Akhileshwar Kumar Srivastava3Kapil D. Pandey4Ajay Kumar5Himanshu Yadav6Center of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, IndiaCenter of Advanced Study in Zoology, Institute of Science, Banaras Hindu University, Varanasi, IndiaUlcer is one of the most common diseases affecting throughout the world population. The allopathic treatment of ulcer adversely affects the health by causing harmful side effects. Currently, many herbal plants and secondary metabolites have been used for the ulcer treatment. In the present review, many herbal plants and their parts (root, rhizome, bark, leaves and fruits) have been listed in the table are currently being used for ulcer treatment. These metabolites are responsible for ulcer-neutralization or anti-inflammatory properties. In silico study, plant metabolites showed interaction between protodioscin (secondary metabolites of Asparagus racemosus) and interferon-γ (virulent factor of gastric ulcer) during molecular docking. All the residues of interferon-γ exhibited hydrophobic interactions with plant metabolites. These interactions helps in understanding the plant secondary metabolites vis a vis will open a new door in the research field of new drug discovery and designing for the ulcer treatment.http://www.sciencedirect.com/science/article/pii/S2215017X17303430Secondary metabolitesUlcerMolecular dockingDrugsMedicinal plants |
| spellingShingle | Amit Kishore Singh Sandeep Kumar Singh Prem Pratap Singh Akhileshwar Kumar Srivastava Kapil D. Pandey Ajay Kumar Himanshu Yadav Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective Biotechnology Reports Secondary metabolites Ulcer Molecular docking Drugs Medicinal plants |
| title | Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective |
| title_full | Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective |
| title_fullStr | Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective |
| title_full_unstemmed | Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective |
| title_short | Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective |
| title_sort | biotechnological aspects of plants metabolites in the treatment of ulcer a new prospective |
| topic | Secondary metabolites Ulcer Molecular docking Drugs Medicinal plants |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X17303430 |
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