Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson’s disease model

Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson’s disease model

Abstract Background Parkinson’s disease (PD), a highly prevalent neuro-motor disorder is caused due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of brain. This leads to depleted dopamine (DA) content at striatum, thus affecting the fine tuning of basal ganglia. In...

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Bibliographic Details
Main Authors: Rupsha Mondal, Chayan Banerjee, Sumangal Nandy, Moumita Roy, Joy Chakraborty
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell & Bioscience
Subjects:
Dopamine toxicity
Mitochondrial fragmentation
Calcineurin
Parkinson’s disease
L-DOPA therapy
Dendritic spine
Online Access:https://doi.org/10.1186/s13578-023-01068-6

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