Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00063/full |
| _version_ | 1818505776550903808 |
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| author | Sandra Carrera-Juliá Sandra Carrera-Juliá Mari Luz Moreno Carlos Barrios Jose Enrique de la Rubia Ortí Eraci Drehmer |
| author_facet | Sandra Carrera-Juliá Sandra Carrera-Juliá Mari Luz Moreno Carlos Barrios Jose Enrique de la Rubia Ortí Eraci Drehmer |
| author_sort | Sandra Carrera-Juliá |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD+) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS. |
| first_indexed | 2024-12-10T21:55:31Z |
| format | Article |
| id | doaj.art-4ac8d60308e44499a80521fd3e44f145 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T21:55:31Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-4ac8d60308e44499a80521fd3e44f1452022-12-22T01:32:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-02-011110.3389/fphys.2020.00063487148Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive ReviewSandra Carrera-Juliá0Sandra Carrera-Juliá1Mari Luz Moreno2Carlos Barrios3Jose Enrique de la Rubia Ortí4Eraci Drehmer5Doctoral Degree’s School, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainDepartment of Nutrition and Dietetics, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainDepartment of Basic Sciences, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainInstitute for Research on Musculoskeletal Disorders, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainDepartment of Basic Medical Sciences, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainDepartment of Basic Sciences, Catholic University of Valencia “San Vicente Mártir”, Valencia, SpainAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD+) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.https://www.frontiersin.org/article/10.3389/fphys.2020.00063/fullamyotrophic lateral sclerosisneurodegenerative diseasesoxidative stressmitochondrial dysfunctionnicotinamide ribosidepterostilbene |
| spellingShingle | Sandra Carrera-Juliá Sandra Carrera-Juliá Mari Luz Moreno Carlos Barrios Jose Enrique de la Rubia Ortí Eraci Drehmer Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review Frontiers in Physiology amyotrophic lateral sclerosis neurodegenerative diseases oxidative stress mitochondrial dysfunction nicotinamide riboside pterostilbene |
| title | Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review |
| title_full | Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review |
| title_fullStr | Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review |
| title_full_unstemmed | Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review |
| title_short | Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review |
| title_sort | antioxidant alternatives in the treatment of amyotrophic lateral sclerosis a comprehensive review |
| topic | amyotrophic lateral sclerosis neurodegenerative diseases oxidative stress mitochondrial dysfunction nicotinamide riboside pterostilbene |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00063/full |
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