Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns
Objectives: to determine the prevalence of pulmonary hemorrhage in newborns and evaluate the associated risk factors and outcomes. Methods: this was a retrospective case-control study involving 67 newborns who met the criteria for pulmonary hemorrhage. A control was selected for each case: the next-...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2014-05-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553614000512 |
| _version_ | 1811255216997138432 |
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| author | Cristina Helena Faleiros Ferreira Fábio Carmona Francisco Eulógio Martinez |
| author_facet | Cristina Helena Faleiros Ferreira Fábio Carmona Francisco Eulógio Martinez |
| author_sort | Cristina Helena Faleiros Ferreira |
| collection | DOAJ |
| description | Objectives: to determine the prevalence of pulmonary hemorrhage in newborns and evaluate the associated risk factors and outcomes.
Methods: this was a retrospective case-control study involving 67 newborns who met the criteria for pulmonary hemorrhage. A control was selected for each case: the next-born child of the same gender, similar weight (± 200 g) and gestational age (± 1 week), with no previous pulmonary hemorrhage and no malformation diagnosis. Factors previous to pulmonary hemorrhage onset, as well as aspects associated to the condition, were assessed.
Results: the prevalence was 6.7 for 1,000 live births, and the rates observed were: 8% among newborns < 1,500 g, and 11% among newborns < 1,000 g. Intubation in the delivery room (OR = 7.16), SNAPPE II (OR = 2.97), surfactant use (OR = 3.7), and blood components used previously to pulmonary hemorrhage onset (OR = 5.91) were associated with pulmonary hemorrhage. In the multivariate logistic regression model, only intubation in delivery room and previous use of blood components maintained the association. Children with pulmonary hemorrhage had higher mortality (OR = 7.24). Among the survivors, the length of stay (p ≤ 0.01) and mechanical ventilation time were longer (OR = 25.6), and oxygen use at 36 weeks of corrected age was higher (OR = 7.67).
Conclusions: pulmonary hemorrhage is more prevalent in premature newborns, and is associated with intubation in the delivery room and previous use of blood components, leading to high mortality and worse clinical evolution. |
| first_indexed | 2024-04-12T17:20:30Z |
| format | Article |
| id | doaj.art-4ac8e56cb9c84144af62ca70028405ea |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T17:20:30Z |
| publishDate | 2014-05-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-4ac8e56cb9c84144af62ca70028405ea2022-12-22T03:23:29ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362014-05-0190331632210.1016/j.jpedp.2014.05.001Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newbornsCristina Helena Faleiros Ferreira0Fábio Carmona1Francisco Eulógio Martinez2Setor de Neonatologia do Hospital das Clínicas de Ribeirão Preto, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, BrasilDepartamento de Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, BrasilDepartamento de Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, BrasilObjectives: to determine the prevalence of pulmonary hemorrhage in newborns and evaluate the associated risk factors and outcomes. Methods: this was a retrospective case-control study involving 67 newborns who met the criteria for pulmonary hemorrhage. A control was selected for each case: the next-born child of the same gender, similar weight (± 200 g) and gestational age (± 1 week), with no previous pulmonary hemorrhage and no malformation diagnosis. Factors previous to pulmonary hemorrhage onset, as well as aspects associated to the condition, were assessed. Results: the prevalence was 6.7 for 1,000 live births, and the rates observed were: 8% among newborns < 1,500 g, and 11% among newborns < 1,000 g. Intubation in the delivery room (OR = 7.16), SNAPPE II (OR = 2.97), surfactant use (OR = 3.7), and blood components used previously to pulmonary hemorrhage onset (OR = 5.91) were associated with pulmonary hemorrhage. In the multivariate logistic regression model, only intubation in delivery room and previous use of blood components maintained the association. Children with pulmonary hemorrhage had higher mortality (OR = 7.24). Among the survivors, the length of stay (p ≤ 0.01) and mechanical ventilation time were longer (OR = 25.6), and oxygen use at 36 weeks of corrected age was higher (OR = 7.67). Conclusions: pulmonary hemorrhage is more prevalent in premature newborns, and is associated with intubation in the delivery room and previous use of blood components, leading to high mortality and worse clinical evolution.http://www.sciencedirect.com/science/article/pii/S2255553614000512Pulmonary hemorrhageNewbornPrematurityBlood componentsMortality |
| spellingShingle | Cristina Helena Faleiros Ferreira Fábio Carmona Francisco Eulógio Martinez Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns Jornal de Pediatria (Versão em Português) Pulmonary hemorrhage Newborn Prematurity Blood components Mortality |
| title | Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| title_full | Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| title_fullStr | Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| title_full_unstemmed | Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| title_short | Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| title_sort | prevalence risk factors and outcomes associated with pulmonary hemorrhage in newborns |
| topic | Pulmonary hemorrhage Newborn Prematurity Blood components Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2255553614000512 |
| work_keys_str_mv | AT cristinahelenafaleirosferreira prevalenceriskfactorsandoutcomesassociatedwithpulmonaryhemorrhageinnewborns AT fabiocarmona prevalenceriskfactorsandoutcomesassociatedwithpulmonaryhemorrhageinnewborns AT franciscoeulogiomartinez prevalenceriskfactorsandoutcomesassociatedwithpulmonaryhemorrhageinnewborns |