Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma

Abstract Background Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the regulation of tumorigenesis. Howbeit, an in‐depth und...

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Bibliographic Details
Main Authors: Ai Zhuang, Xiang Gu, Tongxin Ge, Shaoyun Wang, Shengfang Ge, Peiwei Chai, Renbing Jia, Xianqun Fan
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Cancer Communications
Subjects:
epigenetics
histone deacetylation inhibitors
melanoma
N6‐methyladenine
histone‐RNA crosstalk
Online Access:https://doi.org/10.1002/cac2.12471

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