Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model
Abstract Transcranial Direct Current Stimulation (tDCS) has benefits for motor rehabilitation in stroke patients, but its clinical application is limited due to inter-individual heterogeneous effects. Recently, optimized tDCS that considers individual brain structure has been proposed, but the utili...
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52874-y |
| _version_ | 1797274802628591616 |
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| author | Mi-Jeong Yoon Hye Jung Park Yeun Jie Yoo Hyun Mi Oh Sun Im Tae-Woo Kim Seong Hoon Lim |
| author_facet | Mi-Jeong Yoon Hye Jung Park Yeun Jie Yoo Hyun Mi Oh Sun Im Tae-Woo Kim Seong Hoon Lim |
| author_sort | Mi-Jeong Yoon |
| collection | DOAJ |
| description | Abstract Transcranial Direct Current Stimulation (tDCS) has benefits for motor rehabilitation in stroke patients, but its clinical application is limited due to inter-individual heterogeneous effects. Recently, optimized tDCS that considers individual brain structure has been proposed, but the utility thereof has not been studied in detail. We explored whether optimized tDCS provides unique electrode positions for each patient and creates a higher target electric field than the conventional approach. A comparative within-subject simulation study was conducted using data collected for a randomized controlled study evaluating the effect of optimized tDCS on upper extremity function in stroke patients. Using Neurophet tES LAB 3.0 software, individual brain models were created based on magnetic resonance images and tDCS simulations were performed for each of the conventional and optimized configurations. A comparison of electrode positions between conventional tDCS and optimized tDCS was quantified by calculation of Euclidean distances. A total of 21 stroke patients were studied. Optimized tDCS produced a higher electric field in the hand motor region than conventional tDCS, with an average improvement of 20% and a maximum of 52%. The electrode montage for optimized tDCS was unique to each patient and exhibited various configurations that differed from electrode placement of conventional tDCS. Optimized tDCS afforded a higher electric field in the target of a stroke patient compared to conventional tDCS, which was made possible by appropriately positioning the electrodes. Our findings may encourage further trials on optimized tDCS for motor rehabilitation after stroke. |
| first_indexed | 2024-03-07T15:03:13Z |
| format | Article |
| id | doaj.art-4acbb7a4fceb4a3ab61aeeedb47355cd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:13Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4acbb7a4fceb4a3ab61aeeedb47355cd2024-03-05T19:00:21ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-52874-yElectric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico modelMi-Jeong Yoon0Hye Jung Park1Yeun Jie Yoo2Hyun Mi Oh3Sun Im4Tae-Woo Kim5Seong Hoon Lim6Department of Rehabilitation Medicine, College of Medicine, St. Vincent’s Hospital, The Catholic University of KoreaDepartment of Rehabilitation Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of KoreaDepartment of Rehabilitation Medicine, College of Medicine, St. Vincent’s Hospital, The Catholic University of KoreaDepartment of Rehabilitation Medicine, National Traffic Injury Rehabilitation HospitalDepartment of Rehabilitation Medicine, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Rehabilitation Medicine, National Traffic Injury Rehabilitation HospitalDepartment of Rehabilitation Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of KoreaAbstract Transcranial Direct Current Stimulation (tDCS) has benefits for motor rehabilitation in stroke patients, but its clinical application is limited due to inter-individual heterogeneous effects. Recently, optimized tDCS that considers individual brain structure has been proposed, but the utility thereof has not been studied in detail. We explored whether optimized tDCS provides unique electrode positions for each patient and creates a higher target electric field than the conventional approach. A comparative within-subject simulation study was conducted using data collected for a randomized controlled study evaluating the effect of optimized tDCS on upper extremity function in stroke patients. Using Neurophet tES LAB 3.0 software, individual brain models were created based on magnetic resonance images and tDCS simulations were performed for each of the conventional and optimized configurations. A comparison of electrode positions between conventional tDCS and optimized tDCS was quantified by calculation of Euclidean distances. A total of 21 stroke patients were studied. Optimized tDCS produced a higher electric field in the hand motor region than conventional tDCS, with an average improvement of 20% and a maximum of 52%. The electrode montage for optimized tDCS was unique to each patient and exhibited various configurations that differed from electrode placement of conventional tDCS. Optimized tDCS afforded a higher electric field in the target of a stroke patient compared to conventional tDCS, which was made possible by appropriately positioning the electrodes. Our findings may encourage further trials on optimized tDCS for motor rehabilitation after stroke.https://doi.org/10.1038/s41598-024-52874-y |
| spellingShingle | Mi-Jeong Yoon Hye Jung Park Yeun Jie Yoo Hyun Mi Oh Sun Im Tae-Woo Kim Seong Hoon Lim Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model Scientific Reports |
| title | Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model |
| title_full | Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model |
| title_fullStr | Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model |
| title_full_unstemmed | Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model |
| title_short | Electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients: an in Silico model |
| title_sort | electric field simulation and appropriate electrode positioning for optimized transcranial direct current stimulation of stroke patients an in silico model |
| url | https://doi.org/10.1038/s41598-024-52874-y |
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