Zebrafish—An Optimal Model in Experimental Oncology
A thorough understanding of cancer pathogenesis is a necessary step in the development of more effective and safer therapy. However, due to the complexity of the process and intricate interactions, studying tumor development is an extremely difficult and challenging task. In bringing this issue clos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/13/4223 |
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| author | Iwona Kwiatkowska Justyna Magdalena Hermanowicz Zaneta Iwinska Krystyna Kowalczuk Jolanta Iwanowska Dariusz Pawlak |
| author_facet | Iwona Kwiatkowska Justyna Magdalena Hermanowicz Zaneta Iwinska Krystyna Kowalczuk Jolanta Iwanowska Dariusz Pawlak |
| author_sort | Iwona Kwiatkowska |
| collection | DOAJ |
| description | A thorough understanding of cancer pathogenesis is a necessary step in the development of more effective and safer therapy. However, due to the complexity of the process and intricate interactions, studying tumor development is an extremely difficult and challenging task. In bringing this issue closer, different scientific models with various advancement levels are helpful. Cell cultures is a system that is too simple and does not allow for multidirectional research. On the other hand, rodent models, although commonly used, are burdened with several limitations. For this reason, new model organisms that will allow for the studying of carcinogenesis stages and factors reliably involved in them are urgently sought after. <i>Danio rerio</i>, an inconspicuous fish endowed with unique features, is gaining in importance in the world of scientific research. Including it in oncological research brings solutions to many challenges afflicting modern medicine. This article aims to illustrate the usefulness of <i>Danio rerio</i> as a model organism which turns out to be a powerful and unique tool for studying the stages of carcinogenesis and solving the hitherto incomprehensible processes that lead to the development of the disease. |
| first_indexed | 2024-03-09T04:00:18Z |
| format | Article |
| id | doaj.art-4acc93cae91848889422b9fcf58aee8d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:00:18Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4acc93cae91848889422b9fcf58aee8d2023-12-03T14:13:55ZengMDPI AGMolecules1420-30492022-06-012713422310.3390/molecules27134223Zebrafish—An Optimal Model in Experimental OncologyIwona Kwiatkowska0Justyna Magdalena Hermanowicz1Zaneta Iwinska2Krystyna Kowalczuk3Jolanta Iwanowska4Dariusz Pawlak5Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, PolandDepartment of Integrated Medical Care, Medical University of Bialystok, ul. M Skłodowskiej-Curie 7A, 15-096 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, PolandA thorough understanding of cancer pathogenesis is a necessary step in the development of more effective and safer therapy. However, due to the complexity of the process and intricate interactions, studying tumor development is an extremely difficult and challenging task. In bringing this issue closer, different scientific models with various advancement levels are helpful. Cell cultures is a system that is too simple and does not allow for multidirectional research. On the other hand, rodent models, although commonly used, are burdened with several limitations. For this reason, new model organisms that will allow for the studying of carcinogenesis stages and factors reliably involved in them are urgently sought after. <i>Danio rerio</i>, an inconspicuous fish endowed with unique features, is gaining in importance in the world of scientific research. Including it in oncological research brings solutions to many challenges afflicting modern medicine. This article aims to illustrate the usefulness of <i>Danio rerio</i> as a model organism which turns out to be a powerful and unique tool for studying the stages of carcinogenesis and solving the hitherto incomprehensible processes that lead to the development of the disease.https://www.mdpi.com/1420-3049/27/13/4223zebrafishoncological modeltumor microenvironment |
| spellingShingle | Iwona Kwiatkowska Justyna Magdalena Hermanowicz Zaneta Iwinska Krystyna Kowalczuk Jolanta Iwanowska Dariusz Pawlak Zebrafish—An Optimal Model in Experimental Oncology Molecules zebrafish oncological model tumor microenvironment |
| title | Zebrafish—An Optimal Model in Experimental Oncology |
| title_full | Zebrafish—An Optimal Model in Experimental Oncology |
| title_fullStr | Zebrafish—An Optimal Model in Experimental Oncology |
| title_full_unstemmed | Zebrafish—An Optimal Model in Experimental Oncology |
| title_short | Zebrafish—An Optimal Model in Experimental Oncology |
| title_sort | zebrafish an optimal model in experimental oncology |
| topic | zebrafish oncological model tumor microenvironment |
| url | https://www.mdpi.com/1420-3049/27/13/4223 |
| work_keys_str_mv | AT iwonakwiatkowska zebrafishanoptimalmodelinexperimentaloncology AT justynamagdalenahermanowicz zebrafishanoptimalmodelinexperimentaloncology AT zanetaiwinska zebrafishanoptimalmodelinexperimentaloncology AT krystynakowalczuk zebrafishanoptimalmodelinexperimentaloncology AT jolantaiwanowska zebrafishanoptimalmodelinexperimentaloncology AT dariuszpawlak zebrafishanoptimalmodelinexperimentaloncology |