Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study
Abstract Background Little is known on how denosumab reduces skeletal-related events (SREs) by bone metastases from solid tumors. We sought to evaluate the effect of denosumab administration in patients with bone metastases from solid tumors. Methods Data of patients treated with denosumab were coll...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11495-w |
| _version_ | 1797559015770685440 |
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| author | Kohei Mizuta Hiromichi Oshiro Ryo Katsuki Yuichi Tsuha Yusuke Aoki Yasunori Tome Kotaro Nishida |
| author_facet | Kohei Mizuta Hiromichi Oshiro Ryo Katsuki Yuichi Tsuha Yusuke Aoki Yasunori Tome Kotaro Nishida |
| author_sort | Kohei Mizuta |
| collection | DOAJ |
| description | Abstract Background Little is known on how denosumab reduces skeletal-related events (SREs) by bone metastases from solid tumors. We sought to evaluate the effect of denosumab administration in patients with bone metastases from solid tumors. Methods Data of patients treated with denosumab were collected from electronic medical charts (n = 496). Eligible participants in this study were adult patients (age ≥ 18 years) with metastatic bone lesions from solid tumors treated with denosumab. SREs, surgical interventions, the spinal instability neoplastic score (SINS) for spinal region, and Mirels’ score for the appendicular region were evaluated. To assess whether denosumab could prevent SREs and associated surgery, the SINS and Mirels’ score were compared between patients with and without SREs. Results A total of 247 patients (median age, 65.5 years old; median follow-up period, 13 months) treated with denosumab for metastatic bone lesions from solid tumors were enrolled in this study. SREs occurred in 19 patients (7.7%). SREs occurred in 2 patients (0.8%) who took denosumab administration before SREs. Surgical interventions were undertaken in 14 patients (5.7%) (spinal and intradural lesions in five patients and appendicular lesions in nine patients). The mean SINS of patients without SREs compared to those with SREs were 7.5 points and 10.2 points, respectively. The mean Mirels’ scores of non-SREs patients and those with SREs were 8.07 points and 10.7 points, respectively. Patients with SREs had significantly higher Mirels’ score than non-SREs patients (p < 0.01). Patients with SREs had higher SINS than non-SREs patients (p = 0.09). Conclusions SREs occurred in patients with higher SINS or Mirels’ scores. Two patients suffered from SREs though they took denosumab administration before SREs. Appropriate management of denosumab for patients with bone metastasis is significant. Surgical interventions may be needed for patients who with higher SINS or Mirel’s scores. |
| first_indexed | 2024-03-10T17:39:36Z |
| format | Article |
| id | doaj.art-4acd03576bce454da3ada024cd90dfdc |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-10T17:39:36Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-4acd03576bce454da3ada024cd90dfdc2023-11-20T09:44:24ZengBMCBMC Cancer1471-24072023-10-012311610.1186/s12885-023-11495-wDenosumab administration for bone metastases from solid tumors: a retrospective cross-sectional studyKohei Mizuta0Hiromichi Oshiro1Ryo Katsuki2Yuichi Tsuha3Yusuke Aoki4Yasunori Tome5Kotaro Nishida6Department of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusDepartment of Orthopedic Surgery, Graduate School of Medicine, University of the RyukyusAbstract Background Little is known on how denosumab reduces skeletal-related events (SREs) by bone metastases from solid tumors. We sought to evaluate the effect of denosumab administration in patients with bone metastases from solid tumors. Methods Data of patients treated with denosumab were collected from electronic medical charts (n = 496). Eligible participants in this study were adult patients (age ≥ 18 years) with metastatic bone lesions from solid tumors treated with denosumab. SREs, surgical interventions, the spinal instability neoplastic score (SINS) for spinal region, and Mirels’ score for the appendicular region were evaluated. To assess whether denosumab could prevent SREs and associated surgery, the SINS and Mirels’ score were compared between patients with and without SREs. Results A total of 247 patients (median age, 65.5 years old; median follow-up period, 13 months) treated with denosumab for metastatic bone lesions from solid tumors were enrolled in this study. SREs occurred in 19 patients (7.7%). SREs occurred in 2 patients (0.8%) who took denosumab administration before SREs. Surgical interventions were undertaken in 14 patients (5.7%) (spinal and intradural lesions in five patients and appendicular lesions in nine patients). The mean SINS of patients without SREs compared to those with SREs were 7.5 points and 10.2 points, respectively. The mean Mirels’ scores of non-SREs patients and those with SREs were 8.07 points and 10.7 points, respectively. Patients with SREs had significantly higher Mirels’ score than non-SREs patients (p < 0.01). Patients with SREs had higher SINS than non-SREs patients (p = 0.09). Conclusions SREs occurred in patients with higher SINS or Mirels’ scores. Two patients suffered from SREs though they took denosumab administration before SREs. Appropriate management of denosumab for patients with bone metastasis is significant. Surgical interventions may be needed for patients who with higher SINS or Mirel’s scores.https://doi.org/10.1186/s12885-023-11495-wBone metastasesDenosumabSkeletal-related eventsSpinal instability neoplastic scoreMirels’ score |
| spellingShingle | Kohei Mizuta Hiromichi Oshiro Ryo Katsuki Yuichi Tsuha Yusuke Aoki Yasunori Tome Kotaro Nishida Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study BMC Cancer Bone metastases Denosumab Skeletal-related events Spinal instability neoplastic score Mirels’ score |
| title | Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study |
| title_full | Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study |
| title_fullStr | Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study |
| title_full_unstemmed | Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study |
| title_short | Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study |
| title_sort | denosumab administration for bone metastases from solid tumors a retrospective cross sectional study |
| topic | Bone metastases Denosumab Skeletal-related events Spinal instability neoplastic score Mirels’ score |
| url | https://doi.org/10.1186/s12885-023-11495-w |
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