A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.
Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3315506?pdf=render |
| _version_ | 1818297838998650880 |
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| author | Julia P Brandt Sonya Aziz-Zaman Vaida Juozaityte Luis A Martinez-Velazquez Jakob Gramstrup Petersen Roger Pocock Niels Ringstad |
| author_facet | Julia P Brandt Sonya Aziz-Zaman Vaida Juozaityte Luis A Martinez-Velazquez Jakob Gramstrup Petersen Roger Pocock Niels Ringstad |
| author_sort | Julia P Brandt |
| collection | DOAJ |
| description | Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla. |
| first_indexed | 2024-12-13T04:25:48Z |
| format | Article |
| id | doaj.art-4ad31e8b99eb49fe8561adeecd3f5d54 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T04:25:48Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4ad31e8b99eb49fe8561adeecd3f5d542022-12-21T23:59:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3401410.1371/journal.pone.0034014A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.Julia P BrandtSonya Aziz-ZamanVaida JuozaityteLuis A Martinez-VelazquezJakob Gramstrup PetersenRoger PocockNiels RingstadMany animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla.http://europepmc.org/articles/PMC3315506?pdf=render |
| spellingShingle | Julia P Brandt Sonya Aziz-Zaman Vaida Juozaityte Luis A Martinez-Velazquez Jakob Gramstrup Petersen Roger Pocock Niels Ringstad A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. PLoS ONE |
| title | A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. |
| title_full | A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. |
| title_fullStr | A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. |
| title_full_unstemmed | A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. |
| title_short | A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. |
| title_sort | single gene target of an ets family transcription factor determines neuronal co2 chemosensitivity |
| url | http://europepmc.org/articles/PMC3315506?pdf=render |
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