CES1‐Triggered Liver‐Specific Cargo Release of CRISPR/Cas9 Elements by Cationic Triadic Copolymeric Nanoparticles Targeting Gene Editing of PCSK9 for Hyperlipidemia Amelioration

CES1‐Triggered Liver‐Specific Cargo Release of CRISPR/Cas9 Elements by Cationic Triadic Copolymeric Nanoparticles Targeting Gene Editing of PCSK9 for Hyperlipidemia Amelioration

Abstract The broad application of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 genome editing tools is hindered by challenges in the efficient delivery of its two components into specific cells and intracytoplasmic release. Herein, a novel copolymer for delivery of Cas9‐mRN...

Full description

Bibliographic Details
Main Authors: Yunfei Zhao, Yun Li, Fan Wang, Xuelan Gan, Tianye Zheng, Mengyue Chen, Li Wei, Jun Chen, Chao Yu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
CES active destabilized strategy
CRISPR/Cas9
hyperlipidemia amelioration
liver fixed‐point release
mRNA delivery
PCSK9
Online Access:https://doi.org/10.1002/advs.202300502

Internet

https://doi.org/10.1002/advs.202300502

Similar Items