CES1‐Triggered Liver‐Specific Cargo Release of CRISPR/Cas9 Elements by Cationic Triadic Copolymeric Nanoparticles Targeting Gene Editing of PCSK9 for Hyperlipidemia Amelioration
Abstract The broad application of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 genome editing tools is hindered by challenges in the efficient delivery of its two components into specific cells and intracytoplasmic release. Herein, a novel copolymer for delivery of Cas9‐mRN...
Main Authors: | Yunfei Zhao, Yun Li, Fan Wang, Xuelan Gan, Tianye Zheng, Mengyue Chen, Li Wei, Jun Chen, Chao Yu |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2023-07-01
|
Series: | Advanced Science |
Subjects: | |
Online Access: | https://doi.org/10.1002/advs.202300502 |
Similar Items
-
PCSK9 Associated Promoter Methylation Status
in Patients with Hyperlipidemia
by: Samaneh Bahrami, et al.
Published: (2021-08-01) -
Role of PCSK9 inhibitors in the management of dyslipidaemia
by: Tiny Nair
Published: (2024-03-01) -
VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys
by: Madeline M. Vroom, et al.
Published: (2024-02-01) -
PCSK9: BIOLOGICAL ACTIVITY REGULATION AND CONNECTION WITH LIPID AND CARBOHYDRATE METABOLISM
by: A O Averkova
Published: (2017-09-01) -
PCSK9 gene participates in the development of primary dyslipidemias
by: Matías-Pérez D, et al.
Published: (2021-07-01)