Cartilaginous Organoids: Advances, Applications, and Perspectives
Cartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair, especially articular cartilage repair and reconstruction, has always been a difficult problem in bone tissue engineering. The unique biological characteristics and mechanical structure of articular cartilage make a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-01-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202200114 |
| _version_ | 1797958110289068032 |
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| author | Yuhao Yu Juan Wang Yamin Li Yunsu Chen Wenguo Cui |
| author_facet | Yuhao Yu Juan Wang Yamin Li Yunsu Chen Wenguo Cui |
| author_sort | Yuhao Yu |
| collection | DOAJ |
| description | Cartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair, especially articular cartilage repair and reconstruction, has always been a difficult problem in bone tissue engineering. The unique biological characteristics and mechanical structure of articular cartilage make articular cartilage reconstruction a great challenge. Currently, it is extremely difficult to construct artificial cartilage tissue with all the information of natural cartilage in vitro, which greatly restricts the development of cartilage tissue engineering. Organoid technology is a booming research topic in recent years, which can mimic the complex biological characteristics of organs or tissues in vivo by constructing them in vitro through tissue engineering techniques. Cartilage tissues constructed using organoid technology may provide us with a novel tool to study cartilage development, cartilage pathological processes, and cartilage repair. This review introduces the concept and research progress of cartilage organoids and focuses on the composition and cultivation methods of cartilage organoids and application scenarios, besides giving an outlook on the limitations of present research. |
| first_indexed | 2024-04-11T00:15:13Z |
| format | Article |
| id | doaj.art-4ad4bcf7eae7423c863218f2af459170 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-04-11T00:15:13Z |
| publishDate | 2023-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-4ad4bcf7eae7423c863218f2af4591702023-01-09T04:05:09ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-01-0131n/an/a10.1002/anbr.202200114Cartilaginous Organoids: Advances, Applications, and PerspectivesYuhao Yu0Juan Wang1Yamin Li2Yunsu Chen3Wenguo Cui4Department of Orthopedic Surgery School of Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yishan Road Shanghai 201306 P.R. ChinaDepartment of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital School of Medicine Shanghai Jiao Tong University 197 Ruijin 2nd Road Shanghai 200025 P.R. ChinaDepartment of Orthopedic Surgery School of Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yishan Road Shanghai 201306 P.R. ChinaDepartment of Orthopedic Surgery School of Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yishan Road Shanghai 201306 P.R. ChinaDepartment of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital School of Medicine Shanghai Jiao Tong University 197 Ruijin 2nd Road Shanghai 200025 P.R. ChinaCartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair, especially articular cartilage repair and reconstruction, has always been a difficult problem in bone tissue engineering. The unique biological characteristics and mechanical structure of articular cartilage make articular cartilage reconstruction a great challenge. Currently, it is extremely difficult to construct artificial cartilage tissue with all the information of natural cartilage in vitro, which greatly restricts the development of cartilage tissue engineering. Organoid technology is a booming research topic in recent years, which can mimic the complex biological characteristics of organs or tissues in vivo by constructing them in vitro through tissue engineering techniques. Cartilage tissues constructed using organoid technology may provide us with a novel tool to study cartilage development, cartilage pathological processes, and cartilage repair. This review introduces the concept and research progress of cartilage organoids and focuses on the composition and cultivation methods of cartilage organoids and application scenarios, besides giving an outlook on the limitations of present research.https://doi.org/10.1002/anbr.202200114articular cartilagesbiomaterialscartilaginous organoidsdisease modelsextracellular matrix scaffoldsstem cells |
| spellingShingle | Yuhao Yu Juan Wang Yamin Li Yunsu Chen Wenguo Cui Cartilaginous Organoids: Advances, Applications, and Perspectives Advanced NanoBiomed Research articular cartilages biomaterials cartilaginous organoids disease models extracellular matrix scaffolds stem cells |
| title | Cartilaginous Organoids: Advances, Applications, and Perspectives |
| title_full | Cartilaginous Organoids: Advances, Applications, and Perspectives |
| title_fullStr | Cartilaginous Organoids: Advances, Applications, and Perspectives |
| title_full_unstemmed | Cartilaginous Organoids: Advances, Applications, and Perspectives |
| title_short | Cartilaginous Organoids: Advances, Applications, and Perspectives |
| title_sort | cartilaginous organoids advances applications and perspectives |
| topic | articular cartilages biomaterials cartilaginous organoids disease models extracellular matrix scaffolds stem cells |
| url | https://doi.org/10.1002/anbr.202200114 |
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