Targeting Glutamine Addiction in Gliomas
The most common malignant brain tumors are those of astrocytic origin, gliomas, with the most aggressive glioblastoma (WHO grade IV) among them. Despite efforts, medicine has not made progress in terms of the prognosis and life expectancy of glioma patients. Behind the malignant phenotype of gliomas...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/2/310 |
| _version_ | 1797757594897481728 |
|---|---|
| author | Marta Obara-Michlewska Monika Szeliga |
| author_facet | Marta Obara-Michlewska Monika Szeliga |
| author_sort | Marta Obara-Michlewska |
| collection | DOAJ |
| description | The most common malignant brain tumors are those of astrocytic origin, gliomas, with the most aggressive glioblastoma (WHO grade IV) among them. Despite efforts, medicine has not made progress in terms of the prognosis and life expectancy of glioma patients. Behind the malignant phenotype of gliomas lies multiple genetic mutations leading to reprogramming of their metabolism, which gives those highly proliferating cells an advantage over healthy ones. The so-called glutamine addiction is a metabolic adaptation that supplements oxidative glycolysis in order to secure neoplastic cells with nutrients and energy in unfavorable conditions of hypoxia. The present review aims at presenting the research and clinical attempts targeting the different metabolic pathways involved in glutamine metabolism in gliomas. A brief description of the biochemistry of glutamine transport, synthesis, and glutaminolysis, etc. will forego a detailed comparison of the therapeutic strategies undertaken to inhibit glutamine utilization by gliomas. |
| first_indexed | 2024-03-12T18:18:05Z |
| format | Article |
| id | doaj.art-4ad54157e95a4cd09b0f1abcf271fe31 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T18:18:05Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4ad54157e95a4cd09b0f1abcf271fe312023-08-02T09:02:35ZengMDPI AGCancers2072-66942020-01-0112231010.3390/cancers12020310cancers12020310Targeting Glutamine Addiction in GliomasMarta Obara-Michlewska0Monika Szeliga1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego Street, 02-106 Warsaw, PolandDepartment of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego Street, 02-106 Warsaw, PolandThe most common malignant brain tumors are those of astrocytic origin, gliomas, with the most aggressive glioblastoma (WHO grade IV) among them. Despite efforts, medicine has not made progress in terms of the prognosis and life expectancy of glioma patients. Behind the malignant phenotype of gliomas lies multiple genetic mutations leading to reprogramming of their metabolism, which gives those highly proliferating cells an advantage over healthy ones. The so-called glutamine addiction is a metabolic adaptation that supplements oxidative glycolysis in order to secure neoplastic cells with nutrients and energy in unfavorable conditions of hypoxia. The present review aims at presenting the research and clinical attempts targeting the different metabolic pathways involved in glutamine metabolism in gliomas. A brief description of the biochemistry of glutamine transport, synthesis, and glutaminolysis, etc. will forego a detailed comparison of the therapeutic strategies undertaken to inhibit glutamine utilization by gliomas.https://www.mdpi.com/2072-6694/12/2/310gliomaglutamineglutamateglutaminaseglutamine synthetaseglutamate dehydrogenasetherapy |
| spellingShingle | Marta Obara-Michlewska Monika Szeliga Targeting Glutamine Addiction in Gliomas Cancers glioma glutamine glutamate glutaminase glutamine synthetase glutamate dehydrogenase therapy |
| title | Targeting Glutamine Addiction in Gliomas |
| title_full | Targeting Glutamine Addiction in Gliomas |
| title_fullStr | Targeting Glutamine Addiction in Gliomas |
| title_full_unstemmed | Targeting Glutamine Addiction in Gliomas |
| title_short | Targeting Glutamine Addiction in Gliomas |
| title_sort | targeting glutamine addiction in gliomas |
| topic | glioma glutamine glutamate glutaminase glutamine synthetase glutamate dehydrogenase therapy |
| url | https://www.mdpi.com/2072-6694/12/2/310 |
| work_keys_str_mv | AT martaobaramichlewska targetingglutamineaddictioningliomas AT monikaszeliga targetingglutamineaddictioningliomas |