Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme. Conversion of PpIX to its downstream substrates requires the activity of...

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Bibliographic Details
Main Authors: Jakub Golab, Kamil Bojarczuk, Małgorzata Wańczyk, Magdalena Winiarska, Magdalena Gabrysiak, Małgorzata Firczuk, Angelika Muchowicz, Małgorzata Wachowska
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Molecules
Subjects:
5-aminolevulinic acid
photodynamic therapy
cancer
laser
singlet oxygen
Online Access:http://www.mdpi.com/1420-3049/16/5/4140/

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