Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070
A recent paper in <i>Viruses</i> investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the closely related BK polyomavir...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/89 |
| _version_ | 1797436469818687488 |
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| author | Stian Henriksen Christine Hanssen Rinaldo |
| author_facet | Stian Henriksen Christine Hanssen Rinaldo |
| author_sort | Stian Henriksen |
| collection | DOAJ |
| description | A recent paper in <i>Viruses</i> investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the closely related BK polyomavirus (BKPyV), which may confound results. Scientists need to take this into account and the potential pitfalls. |
| first_indexed | 2024-03-09T11:02:48Z |
| format | Article |
| id | doaj.art-4adee8ebee5f4cbeb37df70762fadfa5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4adee8ebee5f4cbeb37df70762fadfa52023-12-01T01:09:36ZengMDPI AGViruses1999-49152022-12-011518910.3390/v15010089Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070Stian Henriksen0Christine Hanssen Rinaldo1Department of Microbiology and Infection Control, University Hospital of North Norway, N-9038 Tromsø, NorwayDepartment of Microbiology and Infection Control, University Hospital of North Norway, N-9038 Tromsø, NorwayA recent paper in <i>Viruses</i> investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the closely related BK polyomavirus (BKPyV), which may confound results. Scientists need to take this into account and the potential pitfalls.https://www.mdpi.com/1999-4915/15/1/89polyomavirusBKPyVJCPyVSVGp12exosomesmicroRNA |
| spellingShingle | Stian Henriksen Christine Hanssen Rinaldo Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 Viruses polyomavirus BKPyV JCPyV SVGp12 exosomes microRNA |
| title | Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 |
| title_full | Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 |
| title_fullStr | Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 |
| title_full_unstemmed | Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 |
| title_short | Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. <i>Viruses</i> 2022, <i>14</i>, 2070 |
| title_sort | should svgp12 be used for jc polyomavirus studies comment on prezioso et al cos 7 and svgp12 cellular models to study jcpyv replication and microrna expression after infection with archetypal and rearranged nccr viral strains i viruses i 2022 i 14 i 2070 |
| topic | polyomavirus BKPyV JCPyV SVGp12 exosomes microRNA |
| url | https://www.mdpi.com/1999-4915/15/1/89 |
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