Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning
Aim of the study: To present clinical and analytical aspects associated with sodium azide poisoning. The problems were verified on the basis of a case of sodium azide poisoning which was unique due to its circumstances and the development of an analytical method applied for medico-legal practice....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Polish Society of Forensic Medicine and Criminology (PTMSiK)
2016-03-01
|
| Series: | Archives of Forensic Medicine and Criminology |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Clinical-and-analytical-problems-of-sodium-azide-poisonings-as-exemplified-by-a-case-of-fatal-suicidal-poisoning,82,27025,1,1.html |
| _version_ | 1797720756966129664 |
|---|---|
| author | Sebastian Rojek Piotr Hydzik Ewa Gomółka Karol Kula Małgorzata Kłys |
| author_facet | Sebastian Rojek Piotr Hydzik Ewa Gomółka Karol Kula Małgorzata Kłys |
| author_sort | Sebastian Rojek |
| collection | DOAJ |
| description | Aim of the study: To present clinical and analytical aspects associated with sodium azide poisoning. The problems were verified on the basis of a case of sodium azide poisoning which was unique due to its circumstances and the development of an analytical method applied for medico-legal practice.
Material and methods : The object of the study was a toxicological analysis of biological specimens collected from a woman who ingested two doses of sodium azide purchased over the Internet, in a suicide attempt. After the ingestion of the first dose, the clinical management in the form of symptomatic treatment indicated a possibility of recovery. However, the ingestion of a second dose of the xenobiotic, already in the hospital, caused death. Toxicological findings were obtained with the dedicated technique of gas chromatography-mass spectrometry (GC-EI-MS-MS) after extraction combined with derivatization using pentafluorobenzyl bromide (PFBBr).
Results : Post-mortem toxicological studies demonstrated sodium azide in the blood (0.18 mg/l) and urine (6.50 mg/l) samples collected from the woman.
Conclusions : Cases of sodium azide poisoning are rare and difficult to treat, but a review of the literature over a longer interval of time shows that they continue to occur. Therefore, case studies of sodium azide poisoning, together with descriptions of research methodology, can be useful both in clinical terms and in the preparation of toxicological expert opinions for medico-legal purposes. |
| first_indexed | 2024-03-12T09:24:05Z |
| format | Article |
| id | doaj.art-4adf359e613a47f8bf2f389e805eb9c7 |
| institution | Directory Open Access Journal |
| issn | 0324-8267 1689-1716 |
| language | English |
| last_indexed | 2024-03-12T09:24:05Z |
| publishDate | 2016-03-01 |
| publisher | Polish Society of Forensic Medicine and Criminology (PTMSiK) |
| record_format | Article |
| series | Archives of Forensic Medicine and Criminology |
| spelling | doaj.art-4adf359e613a47f8bf2f389e805eb9c72023-09-02T14:20:30ZengPolish Society of Forensic Medicine and Criminology (PTMSiK)Archives of Forensic Medicine and Criminology0324-82671689-17162016-03-0165314515710.5114/amsik.2015.5816027025Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoningSebastian RojekPiotr HydzikEwa GomółkaKarol KulaMałgorzata KłysAim of the study: To present clinical and analytical aspects associated with sodium azide poisoning. The problems were verified on the basis of a case of sodium azide poisoning which was unique due to its circumstances and the development of an analytical method applied for medico-legal practice. Material and methods : The object of the study was a toxicological analysis of biological specimens collected from a woman who ingested two doses of sodium azide purchased over the Internet, in a suicide attempt. After the ingestion of the first dose, the clinical management in the form of symptomatic treatment indicated a possibility of recovery. However, the ingestion of a second dose of the xenobiotic, already in the hospital, caused death. Toxicological findings were obtained with the dedicated technique of gas chromatography-mass spectrometry (GC-EI-MS-MS) after extraction combined with derivatization using pentafluorobenzyl bromide (PFBBr). Results : Post-mortem toxicological studies demonstrated sodium azide in the blood (0.18 mg/l) and urine (6.50 mg/l) samples collected from the woman. Conclusions : Cases of sodium azide poisoning are rare and difficult to treat, but a review of the literature over a longer interval of time shows that they continue to occur. Therefore, case studies of sodium azide poisoning, together with descriptions of research methodology, can be useful both in clinical terms and in the preparation of toxicological expert opinions for medico-legal purposes.http://www.termedia.pl/Clinical-and-analytical-problems-of-sodium-azide-poisonings-as-exemplified-by-a-case-of-fatal-suicidal-poisoning,82,27025,1,1.htmlsodium azide poisoning PFBBr derivatization GC-EI-MS-MS |
| spellingShingle | Sebastian Rojek Piotr Hydzik Ewa Gomółka Karol Kula Małgorzata Kłys Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning Archives of Forensic Medicine and Criminology sodium azide poisoning PFBBr derivatization GC-EI-MS-MS |
| title | Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| title_full | Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| title_fullStr | Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| title_full_unstemmed | Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| title_short | Clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| title_sort | clinical and analytical problems of sodium azide poisonings as exemplified by a case of fatal suicidal poisoning |
| topic | sodium azide poisoning PFBBr derivatization GC-EI-MS-MS |
| url | http://www.termedia.pl/Clinical-and-analytical-problems-of-sodium-azide-poisonings-as-exemplified-by-a-case-of-fatal-suicidal-poisoning,82,27025,1,1.html |
| work_keys_str_mv | AT sebastianrojek clinicalandanalyticalproblemsofsodiumazidepoisoningsasexemplifiedbyacaseoffatalsuicidalpoisoning AT piotrhydzik clinicalandanalyticalproblemsofsodiumazidepoisoningsasexemplifiedbyacaseoffatalsuicidalpoisoning AT ewagomołka clinicalandanalyticalproblemsofsodiumazidepoisoningsasexemplifiedbyacaseoffatalsuicidalpoisoning AT karolkula clinicalandanalyticalproblemsofsodiumazidepoisoningsasexemplifiedbyacaseoffatalsuicidalpoisoning AT małgorzatakłys clinicalandanalyticalproblemsofsodiumazidepoisoningsasexemplifiedbyacaseoffatalsuicidalpoisoning |