The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis
BackgroundCortical plasticity induced by quadripulse stimulation (QPS) has been shown to correlate with cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS) and to not be reduced compared to healthy controls (HCs).ObjectiveThis study aimed to compare the degree of QPS-i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1266225/full |
| _version_ | 1797463605673721856 |
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| author | Carolin Balloff Carolin Balloff Philipp Albrecht Philipp Albrecht Arved-Sebastian Stucke Lina Scala Sveva Novello Christian Johannes Hartmann Christian Johannes Hartmann Sven Günther Meuth Alfons Schnitzler Alfons Schnitzler Iris-Katharina Penner Iris-Katharina Penner Stefan Jun Groiss Stefan Jun Groiss Stefan Jun Groiss |
| author_facet | Carolin Balloff Carolin Balloff Philipp Albrecht Philipp Albrecht Arved-Sebastian Stucke Lina Scala Sveva Novello Christian Johannes Hartmann Christian Johannes Hartmann Sven Günther Meuth Alfons Schnitzler Alfons Schnitzler Iris-Katharina Penner Iris-Katharina Penner Stefan Jun Groiss Stefan Jun Groiss Stefan Jun Groiss |
| author_sort | Carolin Balloff |
| collection | DOAJ |
| description | BackgroundCortical plasticity induced by quadripulse stimulation (QPS) has been shown to correlate with cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS) and to not be reduced compared to healthy controls (HCs).ObjectiveThis study aimed to compare the degree of QPS-induced plasticity between different subtypes of multiple sclerosis (MS) and HCs and to investigate the association of the degree of plasticity with motor and cognitive functions. We expected lower levels of plasticity in patients with progressive MS (PMS) but not RRMS compared to HCs. Furthermore, we expected to find positive correlations with cognitive and motor performance in patients with MS.MethodsQPS-induced plasticity was compared between 34 patients with PMS, 30 patients with RRMS, and 30 HCs using linear mixed-effects models. The degree of QPS-induced cortical plasticity was correlated with various motor and cognitive outcomes.ResultsThere were no differences regarding the degree of QPS-induced cortical plasticity between HCs and patients with RRMS (p = 0.86) and PMS (p = 0.18). However, we only found correlations between the level of induced plasticity and both motor and cognitive functions in patients with intact corticospinal tract integrity. Exploratory analysis revealed significantly reduced QPS-induced plasticity in patients with damage compared to intact corticospinal tract integrity (p < 0.001).ConclusionOur study supports the notion of pyramidal tract integrity being of more relevance for QPS-induced cortical plasticity in MS and related functional significance than the type of disease. |
| first_indexed | 2024-03-09T17:53:08Z |
| format | Article |
| id | doaj.art-4ae0b923d2bf4491b285ea1ea1c7f358 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T17:53:08Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4ae0b923d2bf4491b285ea1ea1c7f3582023-11-24T10:32:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-11-011410.3389/fneur.2023.12662251266225The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosisCarolin Balloff0Carolin Balloff1Philipp Albrecht2Philipp Albrecht3Arved-Sebastian Stucke4Lina Scala5Sveva Novello6Christian Johannes Hartmann7Christian Johannes Hartmann8Sven Günther Meuth9Alfons Schnitzler10Alfons Schnitzler11Iris-Katharina Penner12Iris-Katharina Penner13Stefan Jun Groiss14Stefan Jun Groiss15Stefan Jun Groiss16Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Kliniken Maria Hilf GmbH, Mönchengladbach, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Kliniken Maria Hilf GmbH, Mönchengladbach, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, GermanyNeurocenter Düsseldorf, Düsseldorf, GermanyBackgroundCortical plasticity induced by quadripulse stimulation (QPS) has been shown to correlate with cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS) and to not be reduced compared to healthy controls (HCs).ObjectiveThis study aimed to compare the degree of QPS-induced plasticity between different subtypes of multiple sclerosis (MS) and HCs and to investigate the association of the degree of plasticity with motor and cognitive functions. We expected lower levels of plasticity in patients with progressive MS (PMS) but not RRMS compared to HCs. Furthermore, we expected to find positive correlations with cognitive and motor performance in patients with MS.MethodsQPS-induced plasticity was compared between 34 patients with PMS, 30 patients with RRMS, and 30 HCs using linear mixed-effects models. The degree of QPS-induced cortical plasticity was correlated with various motor and cognitive outcomes.ResultsThere were no differences regarding the degree of QPS-induced cortical plasticity between HCs and patients with RRMS (p = 0.86) and PMS (p = 0.18). However, we only found correlations between the level of induced plasticity and both motor and cognitive functions in patients with intact corticospinal tract integrity. Exploratory analysis revealed significantly reduced QPS-induced plasticity in patients with damage compared to intact corticospinal tract integrity (p < 0.001).ConclusionOur study supports the notion of pyramidal tract integrity being of more relevance for QPS-induced cortical plasticity in MS and related functional significance than the type of disease.https://www.frontiersin.org/articles/10.3389/fneur.2023.1266225/fullcortical plasticitymotor functionrepetitive transcranial magnetic stimulationquadripulse stimulationpyramidal tract integrity |
| spellingShingle | Carolin Balloff Carolin Balloff Philipp Albrecht Philipp Albrecht Arved-Sebastian Stucke Lina Scala Sveva Novello Christian Johannes Hartmann Christian Johannes Hartmann Sven Günther Meuth Alfons Schnitzler Alfons Schnitzler Iris-Katharina Penner Iris-Katharina Penner Stefan Jun Groiss Stefan Jun Groiss Stefan Jun Groiss The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis Frontiers in Neurology cortical plasticity motor function repetitive transcranial magnetic stimulation quadripulse stimulation pyramidal tract integrity |
| title | The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| title_full | The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| title_fullStr | The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| title_full_unstemmed | The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| title_short | The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| title_sort | importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis |
| topic | cortical plasticity motor function repetitive transcranial magnetic stimulation quadripulse stimulation pyramidal tract integrity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1266225/full |
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