Suppression of Coronary Atherosclerosis by Helix B Surface Peptide, a Nonerythropoietic, Tissue-Protective Compound Derived from Erythropoietin

Suppression of Coronary Atherosclerosis by Helix B Surface Peptide, a Nonerythropoietic, Tissue-Protective Compound Derived from Erythropoietin

Abstract Erythropoietin (EPO), a type I cytokine originally identified for its critical role in hematopoiesis, has been shown to have non-hematopoietic, tissue-protective effects, including suppression of atherosclerosis. However, prothrombotic effects of EPO hinder its potential clinical use in non...

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Bibliographic Details
Main Authors: Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakami
Format: Article
Language:English
Published: BMC 2013-05-01
Series:Molecular Medicine
Subjects:
Helix B Surface Peptide
Coronary Atherosclerotic Lesions
Human Umbilical Vein Endothelial Cells (HUVECs)
Antiatherosclerotic Effects
Spontaneous Myocardial Infarction
Online Access:https://doi.org/10.2119/molmed.2013.00037

Internet

https://doi.org/10.2119/molmed.2013.00037

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