Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers
Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s enviro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/12/4000 |
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| author | Katerina Grafanaki Charalabos Antonatos Alexandros Maniatis Antonia Petropoulou Eleftheria Vryzaki Yiannis Vasilopoulos Sophia Georgiou Stamatis Gregoriou |
| author_facet | Katerina Grafanaki Charalabos Antonatos Alexandros Maniatis Antonia Petropoulou Eleftheria Vryzaki Yiannis Vasilopoulos Sophia Georgiou Stamatis Gregoriou |
| author_sort | Katerina Grafanaki |
| collection | DOAJ |
| description | Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders. |
| first_indexed | 2024-03-11T02:18:15Z |
| format | Article |
| id | doaj.art-4ae125f2672040e2a578a2253da75627 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T02:18:15Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4ae125f2672040e2a578a2253da756272023-11-18T10:59:34ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011212400010.3390/jcm12124000Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory LayersKaterina Grafanaki0Charalabos Antonatos1Alexandros Maniatis2Antonia Petropoulou3Eleftheria Vryzaki4Yiannis Vasilopoulos5Sophia Georgiou6Stamatis Gregoriou7Department of Dermatology-Venereology, School of Medicine, University of Patras, 26504 Patras, GreeceLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, GreeceDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, GreeceDepartment of Biochemistry, School of Medicine, University of Patras, 26504 Patras, GreeceDepartment of Dermatology-Venereology, School of Medicine, University of Patras, 26504 Patras, GreeceLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, GreeceDepartment of Dermatology-Venereology, School of Medicine, University of Patras, 26504 Patras, GreeceDepartment of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121 Athens, GreeceAtopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures and their effects. We recently reviewed the extrinsic exposome’s environmental risk factors that contribute to AD. The periods of pregnancy, infancy, and teenage years are recognized as crucial stages in the formation of AD, where the exposome leads to enduring impacts on the immune system. However, research is now focusing on the interactions between intrinsic pathways that are modulated by the extrinsic exposome, including genetic variation, epigenetic modifications, and signals, such as diet, stress, and microbiome interactions. As a result, immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders.https://www.mdpi.com/2077-0383/12/12/4000intrinsic exposomeatopic dermatitismiroRNAsinteractomepregnancy exposome |
| spellingShingle | Katerina Grafanaki Charalabos Antonatos Alexandros Maniatis Antonia Petropoulou Eleftheria Vryzaki Yiannis Vasilopoulos Sophia Georgiou Stamatis Gregoriou Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers Journal of Clinical Medicine intrinsic exposome atopic dermatitis miroRNAs interactome pregnancy exposome |
| title | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
| title_full | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
| title_fullStr | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
| title_full_unstemmed | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
| title_short | Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers |
| title_sort | intrinsic effects of exposome in atopic dermatitis genomics epigenomics and regulatory layers |
| topic | intrinsic exposome atopic dermatitis miroRNAs interactome pregnancy exposome |
| url | https://www.mdpi.com/2077-0383/12/12/4000 |
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