Predictive role of erythrocytes in assessment of COVID-19 outcomes
Introduction. The search for affordable and accurate predictors of the outcome of COVID-19 is extremely important, as it provides the possibility to effectively correct the patient treatment tactics. Aim of the study. To develop simple and accurate criteria based on the dynamics of red blood coun...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2023-07-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/4875/776 |
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| author | Yuri N. Smolyakov Boris I. Kuznik Elena V. Fefelova Lyudmila S. Kazantseva Yuri K. Shapovalov Maria S. Lukyanchuk Sergey A. Lukyanov Konstantin G. Shapovalov |
| author_facet | Yuri N. Smolyakov Boris I. Kuznik Elena V. Fefelova Lyudmila S. Kazantseva Yuri K. Shapovalov Maria S. Lukyanchuk Sergey A. Lukyanov Konstantin G. Shapovalov |
| author_sort | Yuri N. Smolyakov |
| collection | DOAJ |
| description | Introduction. The search for affordable and accurate predictors of the outcome of COVID-19 is extremely important, as it provides the possibility to effectively correct the patient treatment tactics.
Aim of the study. To develop simple and accurate criteria based on the dynamics of red blood counts that predict the outcome of COVID-19.
Materials and methods. Observations were carried out in 125 patients with severe and extremely severe COVID-19, in whom indicators characterizing the state of red blood were determined in dynamics on days 1, 5, 7, 10, 14 and 21 after the hospitalization. ROC analysis was performed to calculate the threshold predictive values for survival and mortality.
Results. The total number of erythrocytes and the level of hemoglobin in severe and extremely severe patients did not go beyond the acceptable limits, although showed a tendency to decrease in the group of fatal cases. On the 1st and 21st days, the number of MacroR in the deceased patients was reduced compared to those in group of survivors. It has been established that the RDW-CV test can predict the outcome of the COVID-19 with a high degree of probability at a relatively early stage of disease. RDW-SD test can be an additional predictive criterion of COVID-19 outcome.
Conclusion. The RDW-CV test can be used as an effective predictor of disease outcome in patients with severe COVID-19. |
| first_indexed | 2024-03-13T00:08:34Z |
| format | Article |
| id | doaj.art-4ae46d9bdf8c48868a726b353888ecc5 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:34Z |
| publishDate | 2023-07-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-4ae46d9bdf8c48868a726b353888ecc52023-07-12T19:31:14ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972023-07-0168319820410.36233/0507-4088-1661167Predictive role of erythrocytes in assessment of COVID-19 outcomesYuri N. Smolyakov0https://orcid.org/0000-0001-7920-7642Boris I. Kuznik1https://orcid.org/0000-0002-2502-9411Elena V. Fefelova2https://orcid.org/0000-0002-0724-0352Lyudmila S. Kazantseva3https://orcid.org/0000-0002-9816-9714Yuri K. Shapovalov4https://orcid.org/0000-0001-6408-239XMaria S. Lukyanchuk5https://orcid.org/0000-0001-9095-8252Sergey A. Lukyanov6https://orcid.org/0000-0001-7997-9116Konstantin G. Shapovalov7https://orcid.org/0000-0002-3485-5176Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyRegional Clinical Infectious Diseases HospitalChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyIntroduction. The search for affordable and accurate predictors of the outcome of COVID-19 is extremely important, as it provides the possibility to effectively correct the patient treatment tactics. Aim of the study. To develop simple and accurate criteria based on the dynamics of red blood counts that predict the outcome of COVID-19. Materials and methods. Observations were carried out in 125 patients with severe and extremely severe COVID-19, in whom indicators characterizing the state of red blood were determined in dynamics on days 1, 5, 7, 10, 14 and 21 after the hospitalization. ROC analysis was performed to calculate the threshold predictive values for survival and mortality. Results. The total number of erythrocytes and the level of hemoglobin in severe and extremely severe patients did not go beyond the acceptable limits, although showed a tendency to decrease in the group of fatal cases. On the 1st and 21st days, the number of MacroR in the deceased patients was reduced compared to those in group of survivors. It has been established that the RDW-CV test can predict the outcome of the COVID-19 with a high degree of probability at a relatively early stage of disease. RDW-SD test can be an additional predictive criterion of COVID-19 outcome. Conclusion. The RDW-CV test can be used as an effective predictor of disease outcome in patients with severe COVID-19.https://virusjour.crie.ru/jour/article/viewFile/4875/776covid-19erythrocytesanisocytosisrdw-cvrdw-sd |
| spellingShingle | Yuri N. Smolyakov Boris I. Kuznik Elena V. Fefelova Lyudmila S. Kazantseva Yuri K. Shapovalov Maria S. Lukyanchuk Sergey A. Lukyanov Konstantin G. Shapovalov Predictive role of erythrocytes in assessment of COVID-19 outcomes Вопросы вирусологии covid-19 erythrocytes anisocytosis rdw-cv rdw-sd |
| title | Predictive role of erythrocytes in assessment of COVID-19 outcomes |
| title_full | Predictive role of erythrocytes in assessment of COVID-19 outcomes |
| title_fullStr | Predictive role of erythrocytes in assessment of COVID-19 outcomes |
| title_full_unstemmed | Predictive role of erythrocytes in assessment of COVID-19 outcomes |
| title_short | Predictive role of erythrocytes in assessment of COVID-19 outcomes |
| title_sort | predictive role of erythrocytes in assessment of covid 19 outcomes |
| topic | covid-19 erythrocytes anisocytosis rdw-cv rdw-sd |
| url | https://virusjour.crie.ru/jour/article/viewFile/4875/776 |
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