Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma
Introduction In the past few years, treatment of multiple myeloma has undergone a deep change for the employment of novel treatment comprising proteasome inhibitors. Bortezomib is a first-line drug in therapy of multiple myeloma. The onset of peripheral neuropathy is a dose-limiting collateral effec...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-01-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Diagnostic-utility-of-Sudoscan-for-detecting-bortezomib-induced-painful-neuropathy,114269,0,2.html |
| _version_ | 1828383607832444928 |
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| author | Alessandro Allegra Vincenzo Rizzo Vanessa Innao Angela Alibrandi Anna Mazzeo Rossana Leanza Carmen Terranova Luca Gentile Paolo Girlanda Andrea Gaetano Allegra Andrea Alonci Caterina Musolino |
| author_facet | Alessandro Allegra Vincenzo Rizzo Vanessa Innao Angela Alibrandi Anna Mazzeo Rossana Leanza Carmen Terranova Luca Gentile Paolo Girlanda Andrea Gaetano Allegra Andrea Alonci Caterina Musolino |
| author_sort | Alessandro Allegra |
| collection | DOAJ |
| description | Introduction
In the past few years, treatment of multiple myeloma has undergone a deep change for the employment of novel treatment comprising proteasome inhibitors. Bortezomib is a first-line drug in therapy of multiple myeloma. The onset of peripheral neuropathy is a dose-limiting collateral effect of the drug. This neuropathy is a distal symmetric neuropathy that affects both large and small fibers. Nerve conduction study (NCS) can be used for the diagnosis of bortezomib neuropathy, but this technique demonstrates alterations of the large nerve fibers. Sudoscan is a novel technique utilized to offer an evaluation of sudomotor function. The main objective of this study was to compare the sensitivity and diagnostic specificity of Sudoscan with respect to the nerve conduction study after bortezomib treatment.
Material and methods
A total of 18 multiple myeloma patients were studied, 10 (55.5%) men and 8 (44.5%) women. Patients were analyzed at baseline and after 6 months of treatment with bortezomib. Subjects were submitted to nerve conduction study and electrochemical skin conductance evaluation with the Sudoscan device. Patients were also submitted to a clinical measure of pain and neuropathy.
Results
At baseline NCS showed that only the mean sural SAP amplitude was below the 2SD lower limit of normal in 3 (16.7%) patients, while at same time we found an alteration of Sudoscan profiles in 2 (11.1%) patients. After 6 months of treatment, the NCS profiles were altered in 13 (72.2%) patients, and the Sudoscan profiles were modified in 11 (61.1%) subjects.
Conclusions
Our results suggest that Sudoscan can be considered for the diagnosis of bortezomib-induced neuropathy. It is objective, reproducible, and surely easier than the traditional nerve conduction study. Sudoscan may be a useful help to manage the therapeutic interventions in multiple myeloma. |
| first_indexed | 2024-12-10T04:52:06Z |
| format | Article |
| id | doaj.art-4ae474683a144f25b8f74c7cf877c99c |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-12-10T04:52:06Z |
| publishDate | 2021-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-4ae474683a144f25b8f74c7cf877c99c2022-12-22T02:01:35ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-01-0118369670310.5114/aoms/114269114269Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myelomaAlessandro Allegra0Vincenzo Rizzo1Vanessa Innao2Angela Alibrandi3Anna Mazzeo4Rossana Leanza5Carmen Terranova6Luca Gentile7Paolo Girlanda8Andrea Gaetano Allegra9Andrea Alonci10Caterina Musolino11Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Italy,Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyDepartment of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy.Department of Clinical and Experimental Medicine, University of Messina, Italy,Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Italy,Department of Clinical and Experimental Medicine, University of Messina, Italy,Department of Clinical and Experimental Medicine, University of Messina, Italy,Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyDivision of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyDivision of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Messina, ItalyIntroduction In the past few years, treatment of multiple myeloma has undergone a deep change for the employment of novel treatment comprising proteasome inhibitors. Bortezomib is a first-line drug in therapy of multiple myeloma. The onset of peripheral neuropathy is a dose-limiting collateral effect of the drug. This neuropathy is a distal symmetric neuropathy that affects both large and small fibers. Nerve conduction study (NCS) can be used for the diagnosis of bortezomib neuropathy, but this technique demonstrates alterations of the large nerve fibers. Sudoscan is a novel technique utilized to offer an evaluation of sudomotor function. The main objective of this study was to compare the sensitivity and diagnostic specificity of Sudoscan with respect to the nerve conduction study after bortezomib treatment. Material and methods A total of 18 multiple myeloma patients were studied, 10 (55.5%) men and 8 (44.5%) women. Patients were analyzed at baseline and after 6 months of treatment with bortezomib. Subjects were submitted to nerve conduction study and electrochemical skin conductance evaluation with the Sudoscan device. Patients were also submitted to a clinical measure of pain and neuropathy. Results At baseline NCS showed that only the mean sural SAP amplitude was below the 2SD lower limit of normal in 3 (16.7%) patients, while at same time we found an alteration of Sudoscan profiles in 2 (11.1%) patients. After 6 months of treatment, the NCS profiles were altered in 13 (72.2%) patients, and the Sudoscan profiles were modified in 11 (61.1%) subjects. Conclusions Our results suggest that Sudoscan can be considered for the diagnosis of bortezomib-induced neuropathy. It is objective, reproducible, and surely easier than the traditional nerve conduction study. Sudoscan may be a useful help to manage the therapeutic interventions in multiple myeloma.https://www.archivesofmedicalscience.com/Diagnostic-utility-of-Sudoscan-for-detecting-bortezomib-induced-painful-neuropathy,114269,0,2.htmlmultiple myelomabortezomibperipheral neuropathysudoscannerve conduction studysudomotor function |
| spellingShingle | Alessandro Allegra Vincenzo Rizzo Vanessa Innao Angela Alibrandi Anna Mazzeo Rossana Leanza Carmen Terranova Luca Gentile Paolo Girlanda Andrea Gaetano Allegra Andrea Alonci Caterina Musolino Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma Archives of Medical Science multiple myeloma bortezomib peripheral neuropathy sudoscan nerve conduction study sudomotor function |
| title | Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma |
| title_full | Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma |
| title_fullStr | Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma |
| title_full_unstemmed | Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma |
| title_short | Diagnostic utility of Sudoscan for detecting bortezomib-induced painful neuropathy: a study on 18 patients with multiple myeloma |
| title_sort | diagnostic utility of sudoscan for detecting bortezomib induced painful neuropathy a study on 18 patients with multiple myeloma |
| topic | multiple myeloma bortezomib peripheral neuropathy sudoscan nerve conduction study sudomotor function |
| url | https://www.archivesofmedicalscience.com/Diagnostic-utility-of-Sudoscan-for-detecting-bortezomib-induced-painful-neuropathy,114269,0,2.html |
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