Analysis of 2′-hydroxyflavanone (2HF) in mouse whole blood by HPLC–MS/MS for the determination of pharmacokinetic parameters

Analysis of 2′-hydroxyflavanone (2HF) in mouse whole blood by HPLC–MS/MS for the determination of pharmacokinetic parameters

Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics. 2′-Hydroxyflavanone (2HF) is a flavonoid that has shown promising results in different types of cancer and leishmanias...

Full description

Bibliographic Details
Main Authors: Luiza F. O. Gervazoni, Gabriella Gonçalves-Ozorio, Taiana Ferreira-Paes, Aline C. A. Silva, Gabriel P. E. Silveira, Heliana M. Pereira, Douglas P. Pinto, Edézio F. Cunha-Junior, Elmo E. Almeida-Amaral
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Chemistry
Subjects:
HPLC-MS/MS
pharmacokinetics
2′-hydroxiflavanone
flavonoid
oral treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1016193/full

Similar Items

Similar Items