Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief
Background and Aims: Injectable paracetamol has analgesic and antipyretic activities, especially used in postoperative period. The aim of this study was to assess the analgesic efficacy and safety of IV paracetamol in comparison with IV diclofenac for postoperative pain relief. Material and Methods:...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2019;volume=35;issue=2;spage=188;epage=191;aulast=Shah |
| _version_ | 1819049938274746368 |
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| author | Ushma D Shah Krunal N Dudhwala Mukesh S Vakil |
| author_facet | Ushma D Shah Krunal N Dudhwala Mukesh S Vakil |
| author_sort | Ushma D Shah |
| collection | DOAJ |
| description | Background and Aims: Injectable paracetamol has analgesic and antipyretic activities, especially used in postoperative period. The aim of this study was to assess the analgesic efficacy and safety of IV paracetamol in comparison with IV diclofenac for postoperative pain relief.
Material and Methods: Randomly selected 120 patients who underwent elective surgery under general anesthesia were divided into two groups: group A (paracetamol group): patients received IV paracetamol (15 mg/kg)/100 mL, 30 min before completion of surgery over the period of 15 min (rounded of to 1 g), the selected cases were in range of 60-70 kg body weight. Group B (diclofenac group): patients received IV diclofenac (1 mg/kg) diluted in 100 mL NS, 30 min before completion of surgery over the period of 15 min (rounded of to 75 mg). Pain relief and side effects were observed in postoperative period. Statistical analysis of continuous data was done by unpaired t-test and Chi-square test was applied for discrete data.
Results: Both IV paracetamol and IV diclofenac were effective for postoperative pain relief. No significant differences were found between them for any measures of analgesic activity. Only minor and common adverse events were reported, with no overall differences between groups.
Conclusion: Both paracetamol and diclofenac drugs are safe to provide analgesia through IV route in postoperative period without any major significant side effects. |
| first_indexed | 2024-12-21T11:40:06Z |
| format | Article |
| id | doaj.art-4ae54ebd5b8f4aa39fdfafd86a9f6576 |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-21T11:40:06Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-4ae54ebd5b8f4aa39fdfafd86a9f65762022-12-21T19:05:19ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852019-01-0135218819110.4103/joacp.JOACP_384_16Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain reliefUshma D ShahKrunal N DudhwalaMukesh S VakilBackground and Aims: Injectable paracetamol has analgesic and antipyretic activities, especially used in postoperative period. The aim of this study was to assess the analgesic efficacy and safety of IV paracetamol in comparison with IV diclofenac for postoperative pain relief. Material and Methods: Randomly selected 120 patients who underwent elective surgery under general anesthesia were divided into two groups: group A (paracetamol group): patients received IV paracetamol (15 mg/kg)/100 mL, 30 min before completion of surgery over the period of 15 min (rounded of to 1 g), the selected cases were in range of 60-70 kg body weight. Group B (diclofenac group): patients received IV diclofenac (1 mg/kg) diluted in 100 mL NS, 30 min before completion of surgery over the period of 15 min (rounded of to 75 mg). Pain relief and side effects were observed in postoperative period. Statistical analysis of continuous data was done by unpaired t-test and Chi-square test was applied for discrete data. Results: Both IV paracetamol and IV diclofenac were effective for postoperative pain relief. No significant differences were found between them for any measures of analgesic activity. Only minor and common adverse events were reported, with no overall differences between groups. Conclusion: Both paracetamol and diclofenac drugs are safe to provide analgesia through IV route in postoperative period without any major significant side effects.http://www.joacp.org/article.asp?issn=0970-9185;year=2019;volume=35;issue=2;spage=188;epage=191;aulast=ShahDiclofenacparacetamolpostoperative pain relief |
| spellingShingle | Ushma D Shah Krunal N Dudhwala Mukesh S Vakil Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief Journal of Anaesthesiology Clinical Pharmacology Diclofenac paracetamol postoperative pain relief |
| title | Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| title_full | Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| title_fullStr | Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| title_full_unstemmed | Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| title_short | Prospective, double-blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| title_sort | prospective double blind randomized study of comparison of analgesic efficacy of parenteral paracetamol and diclofenac for postoperative pain relief |
| topic | Diclofenac paracetamol postoperative pain relief |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2019;volume=35;issue=2;spage=188;epage=191;aulast=Shah |
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