An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses
MicroRNAs (miR) are important regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation. Here the authors show that NF-κB signalling, miR-155 and miR-146a form a complex network of cross-regulations to control gene transcription in macrophages for modulatin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00972-z |
| _version_ | 1819041966124433408 |
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| author | Mati Mann Arnav Mehta Jimmy L. Zhao Kevin Lee Georgi K. Marinov Yvette Garcia-Flores Li-Fan Lu Alexander Y. Rudensky David Baltimore |
| author_facet | Mati Mann Arnav Mehta Jimmy L. Zhao Kevin Lee Georgi K. Marinov Yvette Garcia-Flores Li-Fan Lu Alexander Y. Rudensky David Baltimore |
| author_sort | Mati Mann |
| collection | DOAJ |
| description | MicroRNAs (miR) are important regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation. Here the authors show that NF-κB signalling, miR-155 and miR-146a form a complex network of cross-regulations to control gene transcription in macrophages for modulating inflammatory responses. |
| first_indexed | 2024-12-21T09:33:23Z |
| format | Article |
| id | doaj.art-4ae78de76bc742c580b294dc0c5d59fe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:33:23Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4ae78de76bc742c580b294dc0c5d59fe2022-12-21T19:08:41ZengNature PortfolioNature Communications2041-17232017-10-018111310.1038/s41467-017-00972-zAn NF-κB-microRNA regulatory network tunes macrophage inflammatory responsesMati Mann0Arnav Mehta1Jimmy L. Zhao2Kevin Lee3Georgi K. Marinov4Yvette Garcia-Flores5Li-Fan Lu6Alexander Y. Rudensky7David Baltimore8Division of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDepartment of Medicine, New York Presbyterian Hospital, Weill Cornell Medical CollegeDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biological Sciences, University of CaliforniaHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan-Kettering Cancer CenterDivision of Biology and Biological Engineering, California Institute of TechnologyMicroRNAs (miR) are important regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation. Here the authors show that NF-κB signalling, miR-155 and miR-146a form a complex network of cross-regulations to control gene transcription in macrophages for modulating inflammatory responses.https://doi.org/10.1038/s41467-017-00972-z |
| spellingShingle | Mati Mann Arnav Mehta Jimmy L. Zhao Kevin Lee Georgi K. Marinov Yvette Garcia-Flores Li-Fan Lu Alexander Y. Rudensky David Baltimore An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses Nature Communications |
| title | An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses |
| title_full | An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses |
| title_fullStr | An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses |
| title_full_unstemmed | An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses |
| title_short | An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses |
| title_sort | nf κb microrna regulatory network tunes macrophage inflammatory responses |
| url | https://doi.org/10.1038/s41467-017-00972-z |
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