Stem cell delivery of therapies for brain disorders
Abstract The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-12-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/2001-1326-3-24 |
| _version_ | 1818173770893885440 |
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| author | Alexander Aleynik Kevin M Gernavage Yasmine SH Mourad Lauren S Sherman Katherine Liu Yuriy A Gubenko Pranela Rameshwar |
| author_facet | Alexander Aleynik Kevin M Gernavage Yasmine SH Mourad Lauren S Sherman Katherine Liu Yuriy A Gubenko Pranela Rameshwar |
| author_sort | Alexander Aleynik |
| collection | DOAJ |
| description | Abstract The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles of delivering drugs across the BBB is particularly important for diseases with poor prognosis such as glioblastoma multiforme (GBM). Stem cell treatment to deliver drugs to neural tumors is currently in clinical trial. This method, albeit in the early phase, could be an advantage because stem cells can cross the BBB into the brain. MSCs are particularly interesting because to date, the experimental and clinical evidence showed ‘no alarm signal’ with regards to safety. Additionally, MSCs do not form tumors as other more primitive stem cells such as embryonic stem cells. More importantly, MSCs showed pathotropism by migrating to sites of tissue insult. Due to the ability of MSCs to be transplanted across allogeneic barrier, drug‐engineered MSCs can be available as off‐the‐shelf cells for rapid transplantation. This review discusses the advantages and disadvantages of stem cells to deliver prodrugs, genes and RNA to treat neural disorders. |
| first_indexed | 2024-12-11T19:33:48Z |
| format | Article |
| id | doaj.art-4ae9e3edf2f8459dbec469a3bb98a467 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-11T19:33:48Z |
| publishDate | 2014-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-4ae9e3edf2f8459dbec469a3bb98a4672022-12-22T00:53:12ZengWileyClinical and Translational Medicine2001-13262014-12-0131n/an/a10.1186/2001-1326-3-24Stem cell delivery of therapies for brain disordersAlexander Aleynik0Kevin M Gernavage1Yasmine SH Mourad2Lauren S Sherman3Katherine Liu4Yuriy A Gubenko5Pranela Rameshwar6Graduate School of Biomedical SciencesTexasUSAGraduate School of Biomedical SciencesTexasUSAGraduate School of Biomedical SciencesTexasUSAGraduate School of Biomedical SciencesTexasUSADepartment of AnesthesiologyNew Jersey Medical SchoolRutgers School of Biomedical Health Science07103NewarkNJUSADepartment of AnesthesiologyNew Jersey Medical SchoolRutgers School of Biomedical Health Science07103NewarkNJUSADepartment of Medicine – Division of Hematology/OncologyNew Jersey Medical SchoolRutgers School of Biomedical Health Science07103NewarkNJUSAAbstract The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles of delivering drugs across the BBB is particularly important for diseases with poor prognosis such as glioblastoma multiforme (GBM). Stem cell treatment to deliver drugs to neural tumors is currently in clinical trial. This method, albeit in the early phase, could be an advantage because stem cells can cross the BBB into the brain. MSCs are particularly interesting because to date, the experimental and clinical evidence showed ‘no alarm signal’ with regards to safety. Additionally, MSCs do not form tumors as other more primitive stem cells such as embryonic stem cells. More importantly, MSCs showed pathotropism by migrating to sites of tissue insult. Due to the ability of MSCs to be transplanted across allogeneic barrier, drug‐engineered MSCs can be available as off‐the‐shelf cells for rapid transplantation. This review discusses the advantages and disadvantages of stem cells to deliver prodrugs, genes and RNA to treat neural disorders.https://doi.org/10.1186/2001-1326-3-24Mesenchymal stem cellsGlioblastomaNeural stem cellsTherapy |
| spellingShingle | Alexander Aleynik Kevin M Gernavage Yasmine SH Mourad Lauren S Sherman Katherine Liu Yuriy A Gubenko Pranela Rameshwar Stem cell delivery of therapies for brain disorders Clinical and Translational Medicine Mesenchymal stem cells Glioblastoma Neural stem cells Therapy |
| title | Stem cell delivery of therapies for brain disorders |
| title_full | Stem cell delivery of therapies for brain disorders |
| title_fullStr | Stem cell delivery of therapies for brain disorders |
| title_full_unstemmed | Stem cell delivery of therapies for brain disorders |
| title_short | Stem cell delivery of therapies for brain disorders |
| title_sort | stem cell delivery of therapies for brain disorders |
| topic | Mesenchymal stem cells Glioblastoma Neural stem cells Therapy |
| url | https://doi.org/10.1186/2001-1326-3-24 |
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