Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
ABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2019-09-01
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356&tlng=en |
| _version_ | 1828126583385227264 |
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| author | Leonardo Cruz de Souza Luciano Inácio Mariano Renata Freire de Moraes Paulo Caramelli |
| author_facet | Leonardo Cruz de Souza Luciano Inácio Mariano Renata Freire de Moraes Paulo Caramelli |
| author_sort | Leonardo Cruz de Souza |
| collection | DOAJ |
| description | ABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments. |
| first_indexed | 2024-04-11T15:36:45Z |
| format | Article |
| id | doaj.art-4aeb714a2d834c66a9d5b691671cfcbc |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-04-11T15:36:45Z |
| publishDate | 2019-09-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-4aeb714a2d834c66a9d5b691671cfcbc2022-12-22T04:15:56ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642019-09-0113335636010.1590/1980-57642018dn13-030015Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case studyLeonardo Cruz de Souzahttps://orcid.org/0000-0001-5027-9722Luciano Inácio MarianoRenata Freire de MoraesPaulo CaramelliABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356&tlng=enAlzheimer's diseasefrontotemporal dementiaatypical Alzheimer's diseasebiomarkers |
| spellingShingle | Leonardo Cruz de Souza Luciano Inácio Mariano Renata Freire de Moraes Paulo Caramelli Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study Dementia & Neuropsychologia Alzheimer's disease frontotemporal dementia atypical Alzheimer's disease biomarkers |
| title | Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study |
| title_full | Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study |
| title_fullStr | Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study |
| title_full_unstemmed | Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study |
| title_short | Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study |
| title_sort | behavioral variant of frontotemporal dementia or frontal variant of alzheimer s disease a case study |
| topic | Alzheimer's disease frontotemporal dementia atypical Alzheimer's disease biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356&tlng=en |
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