Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center
Purpose: Sperm cryopreservation before cancer treatment is the most effective method to preserve the fertility of male pa-tients. We present our 21 years experience with sperm cryopreservation for cancer patients, including an examination of se-men quality, the current status of cryopreserved sperm,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society for Sexual Medicine and Andrology
2019-05-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1819087640949948416 |
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| author | Seung-Hun Song Dae Keun Kim Su Ye Sung Young Sun Her Ok-Hee Lee Myoung Hwa Choi Hae Kyung Kim Sang Woo Lyu Dong Suk Kim |
| author_facet | Seung-Hun Song Dae Keun Kim Su Ye Sung Young Sun Her Ok-Hee Lee Myoung Hwa Choi Hae Kyung Kim Sang Woo Lyu Dong Suk Kim |
| author_sort | Seung-Hun Song |
| collection | DOAJ |
| description | Purpose: Sperm cryopreservation before cancer treatment is the most effective method to preserve the fertility of male pa-tients. We present our 21 years experience with sperm cryopreservation for cancer patients, including an examination of se-men quality, the current status of cryopreserved sperm, and the rate of sperm use for assisted reproductive technology (ART).
Materials and Methods: A total of 721 cancer patients at Fertility Center of CHA Gangnam Medical Center successfully per-formed sperm cryopreservation for fertility preservation from January 1996 to December 2016. Medical chart review was used to analyze patient age, marital status, cancer type, semen volume, sperm counts and motility, length of storage, and cur-rent banking status.
Results: The major cancers of the 721 patients were leukemia (28.4%), lymphoma (18.3%), testis cancer (10.0%). The mean age at cryopreservation was 27.0 years, and 111 patients (15.4%) performed sperm cryopreservation during or after cancer treatment. The mean sperm concentration was 66.7±66.3 ×106/mL and the mean sperm motility was 33.8%±16.3%. During median follow-up duration of 75 months (range, 1–226 months), 44 patients (6.1%) used their banked sperm at our fertility center for ART and 9 patients (1.2%) transferred their banked sperm to another center. The median duration from cryopreser-vation to use was 51 months (range, 1–158 months).
Conclusions: Sperm cryopreservation before gonadotoxic treatment is the most reliable method to preserve the fertility of male cancer patients. Sperm cryopreservation should be offered as a standard of care for all men planning cancer therapy. |
| first_indexed | 2024-12-21T21:39:22Z |
| format | Article |
| id | doaj.art-4aefc68d1fe845138554d98afd26181e |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-12-21T21:39:22Z |
| publishDate | 2019-05-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-4aefc68d1fe845138554d98afd26181e2022-12-21T18:49:23ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902019-05-0137221922510.5534/wjmh.180061Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility CenterSeung-Hun Song0Dae Keun Kim1Su Ye Sung2Young Sun Her3Ok-Hee Lee4Myoung Hwa Choi5Hae Kyung Kim6Sang Woo Lyu7Dong Suk Kim8Department of Urology, Fertility Center of CHA Gangnam Medical Center, CHA University College of MedicineDepartment of Urology, CHA Fertility Center, Seoul Station, CHA University College of MedicineFertility Center of CHA Gangnam Medical Center, CHA University College of MedicineFertility Center of CHA Gangnam Medical Center, CHA University College of MedicineFertility Center of CHA Gangnam Medical Center, CHA University College of MedicineFertility Center of CHA Gangnam Medical Center, CHA University College of MedicineFertility Center of CHA Gangnam Medical Center, CHA University College of MedicineDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University College of MedicineDepartment of Urology, Fertility Center of CHA Gangnam Medical Center, CHA University College of MedicinePurpose: Sperm cryopreservation before cancer treatment is the most effective method to preserve the fertility of male pa-tients. We present our 21 years experience with sperm cryopreservation for cancer patients, including an examination of se-men quality, the current status of cryopreserved sperm, and the rate of sperm use for assisted reproductive technology (ART). Materials and Methods: A total of 721 cancer patients at Fertility Center of CHA Gangnam Medical Center successfully per-formed sperm cryopreservation for fertility preservation from January 1996 to December 2016. Medical chart review was used to analyze patient age, marital status, cancer type, semen volume, sperm counts and motility, length of storage, and cur-rent banking status. Results: The major cancers of the 721 patients were leukemia (28.4%), lymphoma (18.3%), testis cancer (10.0%). The mean age at cryopreservation was 27.0 years, and 111 patients (15.4%) performed sperm cryopreservation during or after cancer treatment. The mean sperm concentration was 66.7±66.3 ×106/mL and the mean sperm motility was 33.8%±16.3%. During median follow-up duration of 75 months (range, 1–226 months), 44 patients (6.1%) used their banked sperm at our fertility center for ART and 9 patients (1.2%) transferred their banked sperm to another center. The median duration from cryopreser-vation to use was 51 months (range, 1–158 months). Conclusions: Sperm cryopreservation before gonadotoxic treatment is the most reliable method to preserve the fertility of male cancer patients. Sperm cryopreservation should be offered as a standard of care for all men planning cancer therapy.CryopreservationFertilityNeoplasmsSemen preservation |
| spellingShingle | Seung-Hun Song Dae Keun Kim Su Ye Sung Young Sun Her Ok-Hee Lee Myoung Hwa Choi Hae Kyung Kim Sang Woo Lyu Dong Suk Kim Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center The World Journal of Men's Health Cryopreservation Fertility Neoplasms Semen preservation |
| title | Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center |
| title_full | Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center |
| title_fullStr | Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center |
| title_full_unstemmed | Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center |
| title_short | Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center |
| title_sort | long term experience of sperm cryopreservation in cancer patients in a single fertility center |
| topic | Cryopreservation Fertility Neoplasms Semen preservation |
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