Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives
A series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (2), 8-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Ethiopia
2017-11-01
|
| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | https://www.ajol.info/index.php/bcse/article/view/163113 |
| _version_ | 1818997167723905024 |
|---|---|
| author | K. K. Valluri, I. V. K. Viswanath P. V. V. S. Naga Raju B. Rajasekher B. R. Dasu |
| author_facet | K. K. Valluri, I. V. K. Viswanath P. V. V. S. Naga Raju B. Rajasekher B. R. Dasu |
| author_sort | K. K. Valluri, |
| collection | DOAJ |
| description | A series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (2), 8-fluoro-4-hydrazine thiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (3) and 3-amino-7-fluoro-2-mercapto-3H-pyrimido-[5,4-c]quinolin-4-one (4) as intermediates. The title compounds after structure elucidation were used in vitro to find their antibacterial ability towards different micro-organisms. |
| first_indexed | 2024-12-20T21:41:20Z |
| format | Article |
| id | doaj.art-4af01a739979448bbcb78415761abbe9 |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-12-20T21:41:20Z |
| publishDate | 2017-11-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-4af01a739979448bbcb78415761abbe92022-12-21T19:25:49ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2017-11-01312337344http://dx.doi.org/10.4314/bcse.v31i2.15Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivativesK. K. Valluri,I. V. K. ViswanathP. V. V. S. Naga RajuB. RajasekherB. R. DasuA series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (2), 8-fluoro-4-hydrazine thiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (3) and 3-amino-7-fluoro-2-mercapto-3H-pyrimido-[5,4-c]quinolin-4-one (4) as intermediates. The title compounds after structure elucidation were used in vitro to find their antibacterial ability towards different micro-organisms.https://www.ajol.info/index.php/bcse/article/view/163113SynthesisQuinoline134-thiadiazolo pyrimidinSpectral dataPotential activity |
| spellingShingle | K. K. Valluri, I. V. K. Viswanath P. V. V. S. Naga Raju B. Rajasekher B. R. Dasu Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives Bulletin of the Chemical Society of Ethiopia Synthesis Quinoline 1 3 4-thiadiazolo pyrimidin Spectral data Potential activity |
| title | Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives |
| title_full | Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives |
| title_fullStr | Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives |
| title_full_unstemmed | Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives |
| title_short | Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives |
| title_sort | synthesis and in vitro studies of some new quinoline 1 3 4 thiadiazolo pyrimidin derivatives |
| topic | Synthesis Quinoline 1 3 4-thiadiazolo pyrimidin Spectral data Potential activity |
| url | https://www.ajol.info/index.php/bcse/article/view/163113 |
| work_keys_str_mv | AT kkvalluri synthesisandinvitrostudiesofsomenewquinoline134thiadiazolopyrimidinderivatives AT ivkviswanath synthesisandinvitrostudiesofsomenewquinoline134thiadiazolopyrimidinderivatives AT pvvsnagaraju synthesisandinvitrostudiesofsomenewquinoline134thiadiazolopyrimidinderivatives AT brajasekher synthesisandinvitrostudiesofsomenewquinoline134thiadiazolopyrimidinderivatives AT brdasu synthesisandinvitrostudiesofsomenewquinoline134thiadiazolopyrimidinderivatives |