Sleep-disordered breathing in cystic fibrosis pediatric subjects
Objectives: To describe the frequency of sleep-disordered breathing (SDB) in pediatric cystic fibrosis (CF) and to study associations between polysomnographic respiratory parameters and available clinical information. Methods: This was a retrospective, cross-sectional study....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2019-09-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | http://sleepscience.org.br/export-pdf/645/ssci-12-03-0165.pdf |
| Summary: | Objectives: To describe the frequency of sleep-disordered breathing (SDB) in pediatric cystic fibrosis
(CF) and to study associations between polysomnographic respiratory parameters and available
clinical information. Methods: This was a retrospective, cross-sectional study. The sample data
were obtained from information recorded on patient charts in 2015 and 2016. The study included
all individuals with CF aged from 2 to 20 years for whom records were available for polysomnography
performed within the previous two years. Results: Sixteen individuals with CF (mean age 11 ±
5.6 years old) were included. Polysomnographic respiratory parameter abnormalities were defined
as an apnea-hypopnea index (AHI) exceeding one event per hour of sleep or an oxyhemoglobin
saturation (SpO2) nadir below 90%; observed in 10 subjects (62.5%). Forced expiratory volume in
first second (FEV1) was correlated (r=0.602, p=0.023) with mean sleep SpO2. FEV1 was also negatively
correlated with sleep peak end-tidal carbon dioxide (EtpCO2) (r=-0.645, p=0.024). Additionally,
chronic airway colonization by Pseudomonas aeruginosa was associated with mean EtpCO2
in non-REM sleep (p=0.024). Discussion: SDB was frequently observed in this sample of children
with CF. There was an association between CF respiratory disease progression markers and sleep
breathing parameters in children. Sleep studies appear to be an important tool for assessment of
the respiratory status of these individuals with CF, although further studies are needed, especially
with carbon dioxide sleep analysis. |
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| ISSN: | 1984-0659 1984-0063 |