Polyphenols and Their Effects on Muscle Atrophy and Muscle Health
Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/16/4887 |
| _version_ | 1797522695368212480 |
|---|---|
| author | Takeshi Nikawa Anayt Ulla Iori Sakakibara |
| author_facet | Takeshi Nikawa Anayt Ulla Iori Sakakibara |
| author_sort | Takeshi Nikawa |
| collection | DOAJ |
| description | Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies. |
| first_indexed | 2024-03-10T08:33:04Z |
| format | Article |
| id | doaj.art-4af70d2eff194a1a8415212bd7f99fcc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:33:04Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4af70d2eff194a1a8415212bd7f99fcc2023-11-22T08:53:34ZengMDPI AGMolecules1420-30492021-08-012616488710.3390/molecules26164887Polyphenols and Their Effects on Muscle Atrophy and Muscle HealthTakeshi Nikawa0Anayt Ulla1Iori Sakakibara2Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, JapanDepartment of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, JapanDepartment of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, JapanSkeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies.https://www.mdpi.com/1420-3049/26/16/4887antioxidantspolyphenolsflavonoidmuscle atrophyproteolysismitochondrial dysfunction |
| spellingShingle | Takeshi Nikawa Anayt Ulla Iori Sakakibara Polyphenols and Their Effects on Muscle Atrophy and Muscle Health Molecules antioxidants polyphenols flavonoid muscle atrophy proteolysis mitochondrial dysfunction |
| title | Polyphenols and Their Effects on Muscle Atrophy and Muscle Health |
| title_full | Polyphenols and Their Effects on Muscle Atrophy and Muscle Health |
| title_fullStr | Polyphenols and Their Effects on Muscle Atrophy and Muscle Health |
| title_full_unstemmed | Polyphenols and Their Effects on Muscle Atrophy and Muscle Health |
| title_short | Polyphenols and Their Effects on Muscle Atrophy and Muscle Health |
| title_sort | polyphenols and their effects on muscle atrophy and muscle health |
| topic | antioxidants polyphenols flavonoid muscle atrophy proteolysis mitochondrial dysfunction |
| url | https://www.mdpi.com/1420-3049/26/16/4887 |
| work_keys_str_mv | AT takeshinikawa polyphenolsandtheireffectsonmuscleatrophyandmusclehealth AT anaytulla polyphenolsandtheireffectsonmuscleatrophyandmusclehealth AT iorisakakibara polyphenolsandtheireffectsonmuscleatrophyandmusclehealth |