Characteristics of Smell Identification Test in Patients With Parkinson Disease
Objectives Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which is caused by deposition of Lewy bodies emerging from the olfactory bulb to higher olfactory centers. Early detection of olfactory disorder in the patients with PD may lead to the early diagnosis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2019-05-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-2018-01116.pdf |
| _version_ | 1819133586549243904 |
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| author | Hisami Fujio Go Inokuchi Shun Tatehara Shunsuke Kuroki Yuriko Fukuda Hisamoto Kowa Ken-ichi Nibu |
| author_facet | Hisami Fujio Go Inokuchi Shun Tatehara Shunsuke Kuroki Yuriko Fukuda Hisamoto Kowa Ken-ichi Nibu |
| author_sort | Hisami Fujio |
| collection | DOAJ |
| description | Objectives Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which is caused by deposition of Lewy bodies emerging from the olfactory bulb to higher olfactory centers. Early detection of olfactory disorder in the patients with PD may lead to the early diagnosis and treatment for this refractory disease. Methods Visual analog scale (VAS), Jet Stream Olfactometry, and Japanese smell identification test, Open Essence (OE), were carried out on 39 patients with PD. Thirty-one patients with postviral olfactory disorder (PVOD), which was caused by the olfactory mucosal dysfunction, were also enrolled in this study as control. Results There were no significant differences in detection thresholds (2.2 vs. 1.4, P=0.13), recognition thresholds (3.9 vs. 3.5, P=0.39) and OE (4.8 vs. 4.2, P=0.47) between PVOD and PD, while VAS scores of PVOD and PD were significantly different (2.0 and 6.2, P<0.01). In OE, significant differences were observed in the accuracy rates of menthol (68% vs. 44%, P=0.04) and Indian ink (42% vs. 15%, P=0.01) between PVOD and PD. Of particular interest, patients with PVOD tended to select “no detectable,” while patients with PD tended to select wrong alternative other than “no smell detected.” Conclusion Discrepancy between VAS and OE, and high selected rates of wrong alternative other than “undetectable” in OE might be significant signs of olfactory dysfunction associated with PD. |
| first_indexed | 2024-12-22T09:49:39Z |
| format | Article |
| id | doaj.art-4af756e4af484a939df27a8fd623fb75 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-22T09:49:39Z |
| publishDate | 2019-05-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-4af756e4af484a939df27a8fd623fb752022-12-21T18:30:26ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202019-05-0112220621110.21053/ceo.2018.01116614Characteristics of Smell Identification Test in Patients With Parkinson DiseaseHisami Fujio0Go Inokuchi1Shun Tatehara2Shunsuke Kuroki3Yuriko Fukuda4Hisamoto Kowa5Ken-ichi Nibu6 Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, JapanObjectives Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which is caused by deposition of Lewy bodies emerging from the olfactory bulb to higher olfactory centers. Early detection of olfactory disorder in the patients with PD may lead to the early diagnosis and treatment for this refractory disease. Methods Visual analog scale (VAS), Jet Stream Olfactometry, and Japanese smell identification test, Open Essence (OE), were carried out on 39 patients with PD. Thirty-one patients with postviral olfactory disorder (PVOD), which was caused by the olfactory mucosal dysfunction, were also enrolled in this study as control. Results There were no significant differences in detection thresholds (2.2 vs. 1.4, P=0.13), recognition thresholds (3.9 vs. 3.5, P=0.39) and OE (4.8 vs. 4.2, P=0.47) between PVOD and PD, while VAS scores of PVOD and PD were significantly different (2.0 and 6.2, P<0.01). In OE, significant differences were observed in the accuracy rates of menthol (68% vs. 44%, P=0.04) and Indian ink (42% vs. 15%, P=0.01) between PVOD and PD. Of particular interest, patients with PVOD tended to select “no detectable,” while patients with PD tended to select wrong alternative other than “no smell detected.” Conclusion Discrepancy between VAS and OE, and high selected rates of wrong alternative other than “undetectable” in OE might be significant signs of olfactory dysfunction associated with PD.http://www.e-ceo.org/upload/pdf/ceo-2018-01116.pdfPostviral Olfactory DisorderParkinson DiseaseOpen EssenceSmell Identification Test |
| spellingShingle | Hisami Fujio Go Inokuchi Shun Tatehara Shunsuke Kuroki Yuriko Fukuda Hisamoto Kowa Ken-ichi Nibu Characteristics of Smell Identification Test in Patients With Parkinson Disease Clinical and Experimental Otorhinolaryngology Postviral Olfactory Disorder Parkinson Disease Open Essence Smell Identification Test |
| title | Characteristics of Smell Identification Test in Patients With Parkinson Disease |
| title_full | Characteristics of Smell Identification Test in Patients With Parkinson Disease |
| title_fullStr | Characteristics of Smell Identification Test in Patients With Parkinson Disease |
| title_full_unstemmed | Characteristics of Smell Identification Test in Patients With Parkinson Disease |
| title_short | Characteristics of Smell Identification Test in Patients With Parkinson Disease |
| title_sort | characteristics of smell identification test in patients with parkinson disease |
| topic | Postviral Olfactory Disorder Parkinson Disease Open Essence Smell Identification Test |
| url | http://www.e-ceo.org/upload/pdf/ceo-2018-01116.pdf |
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