MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients

MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients

This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of...

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Bibliographic Details
Main Authors: Weaam Gouda, Esmat Ashour, Yehia Shaker, Wafaa Ezzat
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-12-01
Series:Genes and Diseases
Subjects:
Genetic variants
Metabolic syndrome (MS)
Microsomal triglyceride transfer protein (MTP)
Non-alcoholic fatty liver disease (NAFLD)
PCR-RFLP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304217300624
Description
Summary:This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of MTP gene was evaluated by PCR-RFLP method. The frequency of MTP TT genotype and T allele were significantly higher in NAFLD patients when compared to healthy controls. Moreover, a significant association in MTP gene polymorphism was observed in NAFLD patients with MS compared to NAFLD patients without MS and controls. Our study suggested that MTP 493 G/T gene polymorphism may act as susceptibility biomarker for NAFLD and MS.
ISSN:2352-3042

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