MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2017-12-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304217300624 |
| _version_ | 1827267208787525632 |
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| author | Weaam Gouda Esmat Ashour Yehia Shaker Wafaa Ezzat |
| author_facet | Weaam Gouda Esmat Ashour Yehia Shaker Wafaa Ezzat |
| author_sort | Weaam Gouda |
| collection | DOAJ |
| description | This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of MTP gene was evaluated by PCR-RFLP method. The frequency of MTP TT genotype and T allele were significantly higher in NAFLD patients when compared to healthy controls. Moreover, a significant association in MTP gene polymorphism was observed in NAFLD patients with MS compared to NAFLD patients without MS and controls. Our study suggested that MTP 493 G/T gene polymorphism may act as susceptibility biomarker for NAFLD and MS. |
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| format | Article |
| id | doaj.art-4af79e78f6b54a77a27a9ebcdf03d1bc |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:30:06Z |
| publishDate | 2017-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-4af79e78f6b54a77a27a9ebcdf03d1bc2024-04-28T03:50:23ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422017-12-014422222810.1016/j.gendis.2017.09.002MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patientsWeaam Gouda0Esmat Ashour1Yehia Shaker2Wafaa Ezzat3Biochemistry Dept., National Research Center, Dokki, Giza, EgyptBiochemistry Dept., National Research Center, Dokki, Giza, EgyptBiochemistry Dept., National Research Center, Dokki, Giza, EgyptInternal Medicine Dept., National Research Center, Dokki, Giza, EgyptThis study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of MTP gene was evaluated by PCR-RFLP method. The frequency of MTP TT genotype and T allele were significantly higher in NAFLD patients when compared to healthy controls. Moreover, a significant association in MTP gene polymorphism was observed in NAFLD patients with MS compared to NAFLD patients without MS and controls. Our study suggested that MTP 493 G/T gene polymorphism may act as susceptibility biomarker for NAFLD and MS.http://www.sciencedirect.com/science/article/pii/S2352304217300624Genetic variantsMetabolic syndrome (MS)Microsomal triglyceride transfer protein (MTP)Non-alcoholic fatty liver disease (NAFLD)PCR-RFLP |
| spellingShingle | Weaam Gouda Esmat Ashour Yehia Shaker Wafaa Ezzat MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients Genes and Diseases Genetic variants Metabolic syndrome (MS) Microsomal triglyceride transfer protein (MTP) Non-alcoholic fatty liver disease (NAFLD) PCR-RFLP |
| title | MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients |
| title_full | MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients |
| title_fullStr | MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients |
| title_full_unstemmed | MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients |
| title_short | MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients |
| title_sort | mtp genetic variants associated with non alcoholic fatty liver in metabolic syndrome patients |
| topic | Genetic variants Metabolic syndrome (MS) Microsomal triglyceride transfer protein (MTP) Non-alcoholic fatty liver disease (NAFLD) PCR-RFLP |
| url | http://www.sciencedirect.com/science/article/pii/S2352304217300624 |
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