Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure
PurposeTo evaluate the potential beneficial and synergistic effects of oral intake of a fixed combination of citicoline 500 mg plus homotaurine 50 mg (CIT/HOMO) on retinal ganglion cell (RGC) function in subjects with glaucoma using pattern electroretinogram (PERG) and to investigate the effects on...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Frontiers Media S.A.
2022-04-01
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| Ráidu: | Frontiers in Medicine |
| Fáttát: | |
| Liŋkkat: | https://www.frontiersin.org/articles/10.3389/fmed.2022.882335/full |
| _version_ | 1828499445908504576 |
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| author | Gemma Caterina Maria Rossi Teresa Rolle Annalisa De Silvestri Dario Sisto Alberto Mavilio Alessandra Venera Mirabile Alessia Paviglianiti Beatrice Strano Erica Picasso Gian Maria Pasinetti Giovanni Milano Giulio Ruberto |
| author_facet | Gemma Caterina Maria Rossi Teresa Rolle Annalisa De Silvestri Dario Sisto Alberto Mavilio Alessandra Venera Mirabile Alessia Paviglianiti Beatrice Strano Erica Picasso Gian Maria Pasinetti Giovanni Milano Giulio Ruberto |
| author_sort | Gemma Caterina Maria Rossi |
| collection | DOAJ |
| description | PurposeTo evaluate the potential beneficial and synergistic effects of oral intake of a fixed combination of citicoline 500 mg plus homotaurine 50 mg (CIT/HOMO) on retinal ganglion cell (RGC) function in subjects with glaucoma using pattern electroretinogram (PERG) and to investigate the effects on visual field and quality of life.MethodsConsecutive patients with primary open-angle glaucoma with controlled IOP (<18 mmHg) receiving beta-blockers and prostaglandin analogs alone or as combination therapy (fixed or un-fixed); with stable disease (progression no more than −1 dB/year at the visual field MD); and an early to moderate visual field defect (MD < −12 dB) were randomized to: arm A. topical therapy + CIT/HOMO for 4 months, 2 months of wash out, 4 months of topical therapy alone; arm B. topical therapy alone for 4 months, topical therapy + CIT/HOMO for 4 months, 2 months of wash out. All patients underwent 4 visits: complete ocular examination, visual field, PERG and quality of life assessment (NEI-VFQ25) were performed at each visit.ResultsFifty-seven patients completed the study: 26 in group A and 31 in group B. At the end of the intake period, PERG's P50 and N95 waves recorded a greater amplitude. The increase was statistically significant in the inferior and superior P50 waves amplitude: 0.47 μV (95%CI, 0.02–0.93; p = 0.04) and 0.65 μV (95% CI, 0.16–1.13; p = 0.009), respectively, and in the inferior N95 wave amplitude 0.63 μV (95% CI, 0.22–1.04; p = 0.002). A significantly shorter peak time of 3.3 μV (95% CI, −6.01– −0.54; p = 0.01) was observed for the superior P50 wave only.ConclusionsDaily oral intake of the fixed combination CIT/HOMO for 4 months improved the function of inner retinal cells recorded by PERG in the inferior and in the superior quadrants, independently from IOP reduction. This interesting association could represent a valid option for practicing neuromodulation in patients with glaucoma to prevent disease progression. |
| first_indexed | 2024-12-11T13:24:44Z |
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| id | doaj.art-4af7e5ffc13940a6a2d5a2b2df13001d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T13:24:44Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4af7e5ffc13940a6a2d5a2b2df13001d2022-12-22T01:05:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.882335882335Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular PressureGemma Caterina Maria Rossi0Teresa Rolle1Annalisa De Silvestri2Dario Sisto3Alberto Mavilio4Alessandra Venera Mirabile5Alessia Paviglianiti6Beatrice Strano7Erica Picasso8Gian Maria Pasinetti9Giovanni Milano10Giulio Ruberto11Department of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Surgical Sciences, School of Medicine, University of Turin, Turin, ItalyClinical Epidemiology and Biometric Unit, Scientific Direction, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Neuroscience, Eye Clinic, Aldo Moro University of Bari, Bari, ItalyASL of Brindisi, Brindisi, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyEye Unit, Istituto Beato Palazzolo, Bergamo, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyDepartment of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, ItalyPurposeTo evaluate the potential beneficial and synergistic effects of oral intake of a fixed combination of citicoline 500 mg plus homotaurine 50 mg (CIT/HOMO) on retinal ganglion cell (RGC) function in subjects with glaucoma using pattern electroretinogram (PERG) and to investigate the effects on visual field and quality of life.MethodsConsecutive patients with primary open-angle glaucoma with controlled IOP (<18 mmHg) receiving beta-blockers and prostaglandin analogs alone or as combination therapy (fixed or un-fixed); with stable disease (progression no more than −1 dB/year at the visual field MD); and an early to moderate visual field defect (MD < −12 dB) were randomized to: arm A. topical therapy + CIT/HOMO for 4 months, 2 months of wash out, 4 months of topical therapy alone; arm B. topical therapy alone for 4 months, topical therapy + CIT/HOMO for 4 months, 2 months of wash out. All patients underwent 4 visits: complete ocular examination, visual field, PERG and quality of life assessment (NEI-VFQ25) were performed at each visit.ResultsFifty-seven patients completed the study: 26 in group A and 31 in group B. At the end of the intake period, PERG's P50 and N95 waves recorded a greater amplitude. The increase was statistically significant in the inferior and superior P50 waves amplitude: 0.47 μV (95%CI, 0.02–0.93; p = 0.04) and 0.65 μV (95% CI, 0.16–1.13; p = 0.009), respectively, and in the inferior N95 wave amplitude 0.63 μV (95% CI, 0.22–1.04; p = 0.002). A significantly shorter peak time of 3.3 μV (95% CI, −6.01– −0.54; p = 0.01) was observed for the superior P50 wave only.ConclusionsDaily oral intake of the fixed combination CIT/HOMO for 4 months improved the function of inner retinal cells recorded by PERG in the inferior and in the superior quadrants, independently from IOP reduction. This interesting association could represent a valid option for practicing neuromodulation in patients with glaucoma to prevent disease progression.https://www.frontiersin.org/articles/10.3389/fmed.2022.882335/fullglaucomaciticolinehomotaurinepattern electroretinogram (PERG)neuroprotectionquality of life |
| spellingShingle | Gemma Caterina Maria Rossi Teresa Rolle Annalisa De Silvestri Dario Sisto Alberto Mavilio Alessandra Venera Mirabile Alessia Paviglianiti Beatrice Strano Erica Picasso Gian Maria Pasinetti Giovanni Milano Giulio Ruberto Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure Frontiers in Medicine glaucoma citicoline homotaurine pattern electroretinogram (PERG) neuroprotection quality of life |
| title | Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure |
| title_full | Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure |
| title_fullStr | Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure |
| title_full_unstemmed | Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure |
| title_short | Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure |
| title_sort | multicenter prospective randomized single blind cross over study on the effect of a fixed combination of citicoline 500 mg plus homotaurine 50 mg on pattern electroretinogram perg in patients with open angle glaucoma on well controlled intraocular pressure |
| topic | glaucoma citicoline homotaurine pattern electroretinogram (PERG) neuroprotection quality of life |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.882335/full |
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