Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography
Background: A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway remodeling of bronchiolitis remains unclear. Objectives: Aiming to demonstrate the airway morphological a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/17534666231167351 |
| _version_ | 1797844111848374272 |
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| author | Zhu-Quan Su Ming-Lu Zhong Ming-Yue Fan Wan-Yuan Rao Zi-Qing Zhou Yu Chen Xiao-Bo Chen Chun-Li Tang Chang-Hao Zhong Shi-Yue Li |
| author_facet | Zhu-Quan Su Ming-Lu Zhong Ming-Yue Fan Wan-Yuan Rao Zi-Qing Zhou Yu Chen Xiao-Bo Chen Chun-Li Tang Chang-Hao Zhong Shi-Yue Li |
| author_sort | Zhu-Quan Su |
| collection | DOAJ |
| description | Background: A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway remodeling of bronchiolitis remains unclear. Objectives: Aiming to demonstrate the airway morphological abnormalities of bronchiolitis obliterans (BO) and diffuse panbronchiolitis (DPB) assessed by endobronchial optical coherence tomography (EB-OCT), and elucidate whether spirometric and IOS parameters have correlation with the airway remodeling of bronchiolitis. Methods: We recruited 18 patients with bronchiolitis (BO, n = 9; DPB, n = 9) and 17 control subjects. Assessments of clinical features, St. George’s respiratory questionnaire (SGRQ), chest computed tomography (CT), spirometry, IOS, and EB-OCT were performed in all enrolled subjects. The correlation between EB-OCT and lung function parameters was studied and analyzed. Results: The magnitude of abnormalities of spirometric and IOS parameters was significantly greater in patients with bronchiolitis than that in control subjects ( p < 0.05). Patients with BO had notably lower forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC, maximal mid-expiratory flow (MMEF)% pred and higher resonant frequency (Fres), and area of reactance (AX) than those with DPB ( p < 0.05). The EB-OCT measurement among patients with bronchiolitis and between the bronchus in the left and the right lung demonstrated a heterogeneous distribution of airway calibers, presenting a high intra- and inter-individual variability. Patients with bronchiolitis had notably greater airway wall area ( p < 0.05) compared with control, while BO presented greater magnitude of airway abnormalities than DPB. Fres and the difference in airway resistance at 5 and 20 Hz (R 5 –R 20 ) correlated negatively with medium-sized and small airway inner area, and correlated positively with airway wall area ( p < 0.05), whose correlation coefficients were higher than those of spirometric parameters. Conclusion: Bronchiolitis, BO and DPB, manifested a heterogeneous distribution of airway calibers with significant intra- and inter-individual variability. IOS parameters, rather than spirometry, correlated better with medium-sized and small airway remodeling in bronchiolitis assessed by EB-OCT measurement. |
| first_indexed | 2024-04-09T17:17:06Z |
| format | Article |
| id | doaj.art-4af881c3caf7446089478c72c4bc10ed |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-04-09T17:17:06Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-4af881c3caf7446089478c72c4bc10ed2023-04-19T11:33:46ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662023-04-011710.1177/17534666231167351Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomographyZhu-Quan SuMing-Lu ZhongMing-Yue FanWan-Yuan RaoZi-Qing ZhouYu ChenXiao-Bo ChenChun-Li TangChang-Hao ZhongShi-Yue LiBackground: A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway remodeling of bronchiolitis remains unclear. Objectives: Aiming to demonstrate the airway morphological abnormalities of bronchiolitis obliterans (BO) and diffuse panbronchiolitis (DPB) assessed by endobronchial optical coherence tomography (EB-OCT), and elucidate whether spirometric and IOS parameters have correlation with the airway remodeling of bronchiolitis. Methods: We recruited 18 patients with bronchiolitis (BO, n = 9; DPB, n = 9) and 17 control subjects. Assessments of clinical features, St. George’s respiratory questionnaire (SGRQ), chest computed tomography (CT), spirometry, IOS, and EB-OCT were performed in all enrolled subjects. The correlation between EB-OCT and lung function parameters was studied and analyzed. Results: The magnitude of abnormalities of spirometric and IOS parameters was significantly greater in patients with bronchiolitis than that in control subjects ( p < 0.05). Patients with BO had notably lower forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC, maximal mid-expiratory flow (MMEF)% pred and higher resonant frequency (Fres), and area of reactance (AX) than those with DPB ( p < 0.05). The EB-OCT measurement among patients with bronchiolitis and between the bronchus in the left and the right lung demonstrated a heterogeneous distribution of airway calibers, presenting a high intra- and inter-individual variability. Patients with bronchiolitis had notably greater airway wall area ( p < 0.05) compared with control, while BO presented greater magnitude of airway abnormalities than DPB. Fres and the difference in airway resistance at 5 and 20 Hz (R 5 –R 20 ) correlated negatively with medium-sized and small airway inner area, and correlated positively with airway wall area ( p < 0.05), whose correlation coefficients were higher than those of spirometric parameters. Conclusion: Bronchiolitis, BO and DPB, manifested a heterogeneous distribution of airway calibers with significant intra- and inter-individual variability. IOS parameters, rather than spirometry, correlated better with medium-sized and small airway remodeling in bronchiolitis assessed by EB-OCT measurement.https://doi.org/10.1177/17534666231167351 |
| spellingShingle | Zhu-Quan Su Ming-Lu Zhong Ming-Yue Fan Wan-Yuan Rao Zi-Qing Zhou Yu Chen Xiao-Bo Chen Chun-Li Tang Chang-Hao Zhong Shi-Yue Li Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography Therapeutic Advances in Respiratory Disease |
| title | Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| title_full | Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| title_fullStr | Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| title_full_unstemmed | Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| title_short | Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| title_sort | airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography |
| url | https://doi.org/10.1177/17534666231167351 |
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