The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury
Platelets are traditionally considered to be essential components of primary hemostasis. Recent investigations have revealed that platelets can be activated in patients with sepsis and are implicated in the development of sepsis and sepsis-induced-acute kidney injury (SAKI). In the present study, ti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-02-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2017.1392499 |
| _version_ | 1797684260667129856 |
|---|---|
| author | Xiuhua Li Yusheng Li Kan Shen Hongqiang Li Jianwen Bai |
| author_facet | Xiuhua Li Yusheng Li Kan Shen Hongqiang Li Jianwen Bai |
| author_sort | Xiuhua Li |
| collection | DOAJ |
| description | Platelets are traditionally considered to be essential components of primary hemostasis. Recent investigations have revealed that platelets can be activated in patients with sepsis and are implicated in the development of sepsis and sepsis-induced-acute kidney injury (SAKI). In the present study, ticagrelor was used to induce a mouse model of SAKI by cecal ligation and puncture. It was found that ticagrelor could inhibit platelet activity, decrease the levels of interleukin-1β and serum creatinine, reduce infiltration of neutrophils in renal tissue, and attenuate cell apoptosis in the kidney. The results suggested that ticagrelor could protect renal function by inhibiting inflammation, recruitment of neutrophils into the kidney, and cell apoptosis in renal tissue. Thus, the findings might provide new strategies for preventing SAKI. |
| first_indexed | 2024-03-12T00:26:58Z |
| format | Article |
| id | doaj.art-4af96c0c1a704310b2825eeb32303854 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:58Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-4af96c0c1a704310b2825eeb323038542023-09-15T10:31:58ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-02-0130219920510.1080/09537104.2017.13924991392499The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injuryXiuhua Li0Yusheng Li1Kan Shen2Hongqiang Li3Jianwen Bai4Tongji University School of MedicineTongji University School of MedicineShanghai University of Medicine& Health Sciences Affiliated Zhoupu HospitalTongji University School of MedicineTongji University School of MedicinePlatelets are traditionally considered to be essential components of primary hemostasis. Recent investigations have revealed that platelets can be activated in patients with sepsis and are implicated in the development of sepsis and sepsis-induced-acute kidney injury (SAKI). In the present study, ticagrelor was used to induce a mouse model of SAKI by cecal ligation and puncture. It was found that ticagrelor could inhibit platelet activity, decrease the levels of interleukin-1β and serum creatinine, reduce infiltration of neutrophils in renal tissue, and attenuate cell apoptosis in the kidney. The results suggested that ticagrelor could protect renal function by inhibiting inflammation, recruitment of neutrophils into the kidney, and cell apoptosis in renal tissue. Thus, the findings might provide new strategies for preventing SAKI.http://dx.doi.org/10.1080/09537104.2017.1392499acute kidney injuryapoptosisplateletsepsisticagrelor |
| spellingShingle | Xiuhua Li Yusheng Li Kan Shen Hongqiang Li Jianwen Bai The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury Platelets acute kidney injury apoptosis platelet sepsis ticagrelor |
| title | The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury |
| title_full | The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury |
| title_fullStr | The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury |
| title_full_unstemmed | The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury |
| title_short | The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury |
| title_sort | protective effect of ticagrelor on renal function in a mouse model of sepsis induced acute kidney injury |
| topic | acute kidney injury apoptosis platelet sepsis ticagrelor |
| url | http://dx.doi.org/10.1080/09537104.2017.1392499 |
| work_keys_str_mv | AT xiuhuali theprotectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT yushengli theprotectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT kanshen theprotectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT hongqiangli theprotectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT jianwenbai theprotectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT xiuhuali protectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT yushengli protectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT kanshen protectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT hongqiangli protectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury AT jianwenbai protectiveeffectofticagreloronrenalfunctioninamousemodelofsepsisinducedacutekidneyinjury |