Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry
Following the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required. Tableting manufacturing is one of the most productive in terms of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/12/1/509 |
| _version_ | 1797499493412765696 |
|---|---|
| author | Mihaela Ghita Isabela Birs Dana Copot Ioana Nascu Clara M. Ionescu |
| author_facet | Mihaela Ghita Isabela Birs Dana Copot Ioana Nascu Clara M. Ionescu |
| author_sort | Mihaela Ghita |
| collection | DOAJ |
| description | Following the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required. Tableting manufacturing is one of the most productive in terms of turnover and investment into new sensor technologies is an important decision-making step. This paper proposes a continuous solution to detect changes in material properties, and a control algorithm to aid in minimizing risk at the end-product line. Some of the sub-processes involved in tableting manufacturing perform changes in powder and liquid mixtures, granulation, density, therefore changing flow conditions of the raw material. Using impedance spectroscopy in a continuous sensing and monitoring context, it is possible to perform online identification of generalized (fractional) order parametric models where the coefficients are correlated to changes in material properties. The model parameters are then included in a self-tuning control gain used in ratio control as part of the local process control loop. The solution proposed here is easy to implement and poses a significant added value to the current state of art in pharmaceutical manufacturing technologies. |
| first_indexed | 2024-03-10T03:48:10Z |
| format | Article |
| id | doaj.art-4afa5d41c9b54779b95c9bce9a79a2e4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T03:48:10Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-4afa5d41c9b54779b95c9bce9a79a2e42023-11-23T11:14:10ZengMDPI AGApplied Sciences2076-34172022-01-0112150910.3390/app12010509Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical IndustryMihaela Ghita0Isabela Birs1Dana Copot2Ioana Nascu3Clara M. Ionescu4DySC Research Group on Dynamical Systems and Control, Department of Electromechanical, Systems and Metal Engineering, Ghent University, Tech Lane Science Park 125, B9052 Ghent, BelgiumDySC Research Group on Dynamical Systems and Control, Department of Electromechanical, Systems and Metal Engineering, Ghent University, Tech Lane Science Park 125, B9052 Ghent, BelgiumDySC Research Group on Dynamical Systems and Control, Department of Electromechanical, Systems and Metal Engineering, Ghent University, Tech Lane Science Park 125, B9052 Ghent, BelgiumDepartment of Automation, Technical University of Cluj-Napoca, Memorandumului 28, 400114 Cluj-Napoca, RomaniaDySC Research Group on Dynamical Systems and Control, Department of Electromechanical, Systems and Metal Engineering, Ghent University, Tech Lane Science Park 125, B9052 Ghent, BelgiumFollowing the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required. Tableting manufacturing is one of the most productive in terms of turnover and investment into new sensor technologies is an important decision-making step. This paper proposes a continuous solution to detect changes in material properties, and a control algorithm to aid in minimizing risk at the end-product line. Some of the sub-processes involved in tableting manufacturing perform changes in powder and liquid mixtures, granulation, density, therefore changing flow conditions of the raw material. Using impedance spectroscopy in a continuous sensing and monitoring context, it is possible to perform online identification of generalized (fractional) order parametric models where the coefficients are correlated to changes in material properties. The model parameters are then included in a self-tuning control gain used in ratio control as part of the local process control loop. The solution proposed here is easy to implement and poses a significant added value to the current state of art in pharmaceutical manufacturing technologies.https://www.mdpi.com/2076-3417/12/1/509anomalous diffusionmaterial memoryporous materialspharmaceutical industrytabletingcontinuous manufacturing |
| spellingShingle | Mihaela Ghita Isabela Birs Dana Copot Ioana Nascu Clara M. Ionescu Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry Applied Sciences anomalous diffusion material memory porous materials pharmaceutical industry tableting continuous manufacturing |
| title | Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry |
| title_full | Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry |
| title_fullStr | Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry |
| title_full_unstemmed | Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry |
| title_short | Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry |
| title_sort | impedance spectroscopy sensing material properties for self tuning ratio control in pharmaceutical industry |
| topic | anomalous diffusion material memory porous materials pharmaceutical industry tableting continuous manufacturing |
| url | https://www.mdpi.com/2076-3417/12/1/509 |
| work_keys_str_mv | AT mihaelaghita impedancespectroscopysensingmaterialpropertiesforselftuningratiocontrolinpharmaceuticalindustry AT isabelabirs impedancespectroscopysensingmaterialpropertiesforselftuningratiocontrolinpharmaceuticalindustry AT danacopot impedancespectroscopysensingmaterialpropertiesforselftuningratiocontrolinpharmaceuticalindustry AT ioananascu impedancespectroscopysensingmaterialpropertiesforselftuningratiocontrolinpharmaceuticalindustry AT claramionescu impedancespectroscopysensingmaterialpropertiesforselftuningratiocontrolinpharmaceuticalindustry |