Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
Abstract Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-022-00358-y |
| _version_ | 1811309242528825344 |
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| author | Chen Wang Taiyang Ye Wenjing Wang Keqi Song Jie Zhu Lan Dai Wen Di |
| author_facet | Chen Wang Taiyang Ye Wenjing Wang Keqi Song Jie Zhu Lan Dai Wen Di |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Abstract Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compared with ovarian primary tumors in EOC patients. In vitro, inhibition of SphK1 suppressed the metastatic ability of EOC induced by adipocytes. In vivo, blockage of SphK1 could attenuate the omental metastasis of EOC. Importantly, SphK1 modulates adipocyte-induced E/N-cadherin switch through Twist1, a key process in EOC metastasis. Our study reveals a previously unrecognized role of SphK1 in modulating the metastatic tropism of EOC to the adipocyte-rich niche, suggesting a new target for EOC therapy. |
| first_indexed | 2024-04-13T09:38:45Z |
| format | Article |
| id | doaj.art-4afac96bcb364788b34ada6cdc555f18 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-04-13T09:38:45Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-4afac96bcb364788b34ada6cdc555f182022-12-22T02:52:00ZengBMCExperimental Hematology & Oncology2162-36192022-11-011111610.1186/s40164-022-00358-ySphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich nicheChen Wang0Taiyang Ye1Wenjing Wang2Keqi Song3Jie Zhu4Lan Dai5Wen Di6Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compared with ovarian primary tumors in EOC patients. In vitro, inhibition of SphK1 suppressed the metastatic ability of EOC induced by adipocytes. In vivo, blockage of SphK1 could attenuate the omental metastasis of EOC. Importantly, SphK1 modulates adipocyte-induced E/N-cadherin switch through Twist1, a key process in EOC metastasis. Our study reveals a previously unrecognized role of SphK1 in modulating the metastatic tropism of EOC to the adipocyte-rich niche, suggesting a new target for EOC therapy.https://doi.org/10.1186/s40164-022-00358-ySphingosine kinase 1 (SphK1)AdipocyteOvarian cancerMetastasis |
| spellingShingle | Chen Wang Taiyang Ye Wenjing Wang Keqi Song Jie Zhu Lan Dai Wen Di Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche Experimental Hematology & Oncology Sphingosine kinase 1 (SphK1) Adipocyte Ovarian cancer Metastasis |
| title | Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche |
| title_full | Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche |
| title_fullStr | Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche |
| title_full_unstemmed | Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche |
| title_short | Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche |
| title_sort | sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte rich niche |
| topic | Sphingosine kinase 1 (SphK1) Adipocyte Ovarian cancer Metastasis |
| url | https://doi.org/10.1186/s40164-022-00358-y |
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