Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche

Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche

Abstract Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compa...

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Bibliographic Details
Main Authors: Chen Wang, Taiyang Ye, Wenjing Wang, Keqi Song, Jie Zhu, Lan Dai, Wen Di
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Experimental Hematology & Oncology
Subjects:
Sphingosine kinase 1 (SphK1)
Adipocyte
Ovarian cancer
Metastasis
Online Access:https://doi.org/10.1186/s40164-022-00358-y

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