Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice
Background:To evaluate the effect of indomethacin on gastric mucosa of mice and to study the effect of Vitamin E on Indomethacin treated gastric mucosa. Methods: In this experimental study 48 adult male mice were randomly divided into four groups ,comprising of 12 mice each. Group A was labelled as...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2018-09-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/937 |
| _version_ | 1818143228338110464 |
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| author | Ayesha Yousaf et al., |
| author_facet | Ayesha Yousaf et al., |
| author_sort | Ayesha Yousaf et al., |
| collection | DOAJ |
| description | Background:To evaluate the effect of indomethacin on gastric mucosa of mice and to study the effect of Vitamin E on Indomethacin treated gastric mucosa.
Methods: In this experimental study 48 adult male mice were randomly divided into four groups ,comprising of 12 mice each. Group A was labelled as the control group. Evion 400mg/kg was given to group B. Indocid 25mg/kg was administered to group C. Combination of Indocid and Evion (25mg/kg & 400 mg/kg respectively) was given to group D. Dose was administered for three days to 6 mice of each group and for eight days to other 6 mice. Their body weights at the beginning and end of experiment were noted. Stomach was dissected, washed and fixed. The histological parameters observed were epithelial integrity and haemorrhage.
Results: In group A and B findings were normal. Weight of animals in group C was significantly decreased as compared to group D (p-value<0.05). Disturbed integrity of gastric mucosa and haemorrhages were seen in group C.
Conclusion: Indomethacin produced gastric ulcers were decreased by giving Vitamin E in mice. |
| first_indexed | 2024-12-11T11:28:20Z |
| format | Article |
| id | doaj.art-4afe5b55cb974a9ba6f2c83258d782a2 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T11:28:20Z |
| publishDate | 2018-09-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-4afe5b55cb974a9ba6f2c83258d782a22022-12-22T01:08:56ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702018-09-01Effect of Vitamin E on Indomethacin Induced Gastropathy in MiceAyesha Yousaf et al.,0Department of Anatomy, Rawalpindi Medical UniversityBackground:To evaluate the effect of indomethacin on gastric mucosa of mice and to study the effect of Vitamin E on Indomethacin treated gastric mucosa. Methods: In this experimental study 48 adult male mice were randomly divided into four groups ,comprising of 12 mice each. Group A was labelled as the control group. Evion 400mg/kg was given to group B. Indocid 25mg/kg was administered to group C. Combination of Indocid and Evion (25mg/kg & 400 mg/kg respectively) was given to group D. Dose was administered for three days to 6 mice of each group and for eight days to other 6 mice. Their body weights at the beginning and end of experiment were noted. Stomach was dissected, washed and fixed. The histological parameters observed were epithelial integrity and haemorrhage. Results: In group A and B findings were normal. Weight of animals in group C was significantly decreased as compared to group D (p-value<0.05). Disturbed integrity of gastric mucosa and haemorrhages were seen in group C. Conclusion: Indomethacin produced gastric ulcers were decreased by giving Vitamin E in mice.https://www.journalrmc.com/index.php/JRMC/article/view/937Peptic Ulcer Disease (PUD),Vitamin E,Gastric mucosaIndomethacin |
| spellingShingle | Ayesha Yousaf et al., Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice Journal of Rawalpindi Medical College Peptic Ulcer Disease (PUD), Vitamin E, Gastric mucosa Indomethacin |
| title | Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice |
| title_full | Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice |
| title_fullStr | Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice |
| title_full_unstemmed | Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice |
| title_short | Effect of Vitamin E on Indomethacin Induced Gastropathy in Mice |
| title_sort | effect of vitamin e on indomethacin induced gastropathy in mice |
| topic | Peptic Ulcer Disease (PUD), Vitamin E, Gastric mucosa Indomethacin |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/937 |
| work_keys_str_mv | AT ayeshayousafetal effectofvitamineonindomethacininducedgastropathyinmice |