The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

Adaptive immune responses are triggered by antigenic peptides presented on major histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous cells. Formation of stable peptide-MHC I complexes is facilitated by tapasin and TAPBPR, two related MHC I-specific chaperones...

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Bibliographic Details
Main Authors: Lina Sagert, Christian Winter, Ina Ruppert, Maximilian Zehetmaier, Christoph Thomas, Robert Tampé
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
antigen processing
ER quality control
MHC I chaperones
glycoproteins
adaptive immunity
peptide editing
Online Access:https://elifesciences.org/articles/85432

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