Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria
Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/17/6145 |
| Summary: | Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties were very weak, with fluorescence quantum yields in the range of only 0.002–0.051. What is important, they revealed moderate abilities to form singlet oxygen with the quantum yields up to 0.27. Under irradiation, the macrocycles decomposed via photobleaching mechanism with the quantum yields up to 8.64 × 10<sup>−5</sup>. The photokilling potential of tribenzoporphyrazines was assessed against <i>Streptococcus pyogenes</i>, <i>Staphylococcus epidermidis</i>, as well as various strains of <i>Staphylococcus aureus</i>, including methicillin-sensitive and-resistant bacteria. Both evaluated photosensitizers revealed high photodynamic potential against studied bacteria (>3 logs). <i>S.</i><i>aureus</i> growth was reduced by over 5.9 log, methicillin-resistant <i>S. aureus</i> by 5.1 log, <i>S.</i><i>epidermidis</i> by over 5.7 log, and <i>S. pyogenes</i> by over 4.7 log. |
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| ISSN: | 1661-6596 1422-0067 |