DNA damage in homocystinuria: 8-oxo‑,8‑dihydro‑2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl‑L‑cysteine

DNA damage in homocystinuria: 8-oxo‑,8‑dihydro‑2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl‑L‑cysteine

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Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous studies indicate the occurrence of DNA damage seco...

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Bibliografische gegevens
Hoofdauteurs: Camila Simioni Vanzin, Caroline Paula Mescka, Bruna Donida, Desirèe Padilha Marchetti, Carlos Eduardo Jacques, Tatiane Hauschild, Jéssica Lamberty Faverzani, Marion Deon, Dinara Moura, Jenifer Saffi, Daniella de Moura Coelho, Moacir Wajner, Angela T.S. Wyse, Carmen Regla Vargas
Formaat: Artikel
Taal:English
Gepubliceerd in: Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) 2018-04-01
Reeks:Clinical and Biomedical Research
Onderwerpen:
Cystathionine-β-synthase deficiency
oxidative stress
8-oxo-7,8-dihydro- 2’-deoxyguanosine
homocysteine
DNA damage
N-acetyl-L-cysteine
Online toegang:http://seer.ufrgs.br/hcpa/article/view/76977

Internet

http://seer.ufrgs.br/hcpa/article/view/76977

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