1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

Neuropathic pain is a devastating neurological disease that seriously affects quality of life in patients. The mechanisms leading to the development and maintenance of neuropathic pain are still poorly understood. However, recent evidence points towards a role of spinal microglia in the modulation o...

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Bibliographic Details
Main Authors: L. Luongo, E. Palazzo, S. Tambaro, C. Giordano, L. Gatta, M.A. Scafuro, F.sca Rossi, P. Lazzari, L. Pani, V. de Novellis, M. Malcangio, S. Maione
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
Neuropathic pain
Microglia
CB2receptor
Endocannabinoids
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002733

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