The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities
Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/9/1227 |
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| author | Iason Psilopatis Kleio Vrettou Florian Nima Fleckenstein Stamatios Theocharis |
| author_facet | Iason Psilopatis Kleio Vrettou Florian Nima Fleckenstein Stamatios Theocharis |
| author_sort | Iason Psilopatis |
| collection | DOAJ |
| description | Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the particular role of HDACs and their inhibitors in the context of endometriosis. HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, are the five most studied HDAC enzymes which seem to, at least partly, influence the pathophysiology of endometriosis. Both well-established and novel HDACIs could possibly represent modern, efficacious anti-endometriotic drug agents. Altogether, histone modifications and their therapeutic targeting have been proven to have a strong impact on endometriosis. |
| first_indexed | 2024-03-11T04:22:09Z |
| format | Article |
| id | doaj.art-4b00c1777c49446d86170716c7337bc1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T04:22:09Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4b00c1777c49446d86170716c7337bc12023-11-17T22:43:04ZengMDPI AGCells2073-44092023-04-01129122710.3390/cells12091227The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic OpportunitiesIason Psilopatis0Kleio Vrettou1Florian Nima Fleckenstein2Stamatios Theocharis3Department of Diagnostic and Interventional Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt—Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceDepartment of Diagnostic and Interventional Radiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt—Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceEndometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the particular role of HDACs and their inhibitors in the context of endometriosis. HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, are the five most studied HDAC enzymes which seem to, at least partly, influence the pathophysiology of endometriosis. Both well-established and novel HDACIs could possibly represent modern, efficacious anti-endometriotic drug agents. Altogether, histone modifications and their therapeutic targeting have been proven to have a strong impact on endometriosis.https://www.mdpi.com/2073-4409/12/9/1227histonedeacetylaseinhibitorendometriosistherapy |
| spellingShingle | Iason Psilopatis Kleio Vrettou Florian Nima Fleckenstein Stamatios Theocharis The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities Cells histone deacetylase inhibitor endometriosis therapy |
| title | The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities |
| title_full | The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities |
| title_fullStr | The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities |
| title_full_unstemmed | The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities |
| title_short | The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities |
| title_sort | impact of histone modifications in endometriosis highlights new therapeutic opportunities |
| topic | histone deacetylase inhibitor endometriosis therapy |
| url | https://www.mdpi.com/2073-4409/12/9/1227 |
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